Regeneration of insulin- producing cells from wharton{u2019}s jelly mesenchymal stem cells for the treatment of type Ї diabetes mellitus / (Record no. 53703)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03003cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031347.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151202s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.25.M.Sc.2015.Na.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nancy Mohamed Saad Elhossary |
| 245 10 - TITLE STATEMENT | |
| Title | Regeneration of insulin- producing cells from wharton{u2019}s jelly mesenchymal stem cells for the treatment of type Ї diabetes mellitus / |
| Statement of responsibility, etc. | Nancy Mohamed Saad Elhossary ; Supervised Amr Saad Elsayed , Hamdy Mahmoud Hassanein , Abdelwahab AbouBakr Elghareeb |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تجدد الخلايا المىتجة للإنسولين من الخلايا الجذعية الوسيطة لهلام وارتون لعلاج مرض البول السكرى من النوع الاول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nancy Mohamed Saad Elhossary , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 77 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Regenerative medicine represents one of the main concerns of medicine. The aim of this study is to investigate an alternative technique for islet transplantation to treat type Ї diabetes mellitus (T1DM) by efficiently inducing easily obtained and processed Wharton{u2019}s jelly {u2013} derived mesenchymal stem cells of human umbilical cord (huMSCs) to differentiate into islet-like cells (ILCs). HuMSCs were isolated, cultured and induced chemically by fibronectin to differentiate in vitro into ILCs). The response of huMSCs was observed under an inverted microscope and evaluated by flow cytometry, H&E staining and immunocytochemistry. Twenty five male albino rats were divided into five groups, one of which was used as a control. Four groups were injected with 30 mg/kg of streptozotocin (STZ) on 3 consecutive days to induce T1DM. 5{u00D7}10⁶ of the differentiated huMSCs into functional insulin-producing cells were transplanted into two STZ-induced diabetic groups via two various ways , one via the tail vein and the other was intraperitoneally .While, 5{u00D7}10⁶ of the undifferentiated huMSCs were transplanted into the third group via the tail vein. Random blood glucose level (RBGL) and body weight (B.wt) were monitored weekly. After eight weeks, all rats were sacrificed and the pancreatic tissue was harvested in order to examine the change of pancreatic islets{u2019} structure, area and diameter by histomorphologic and histomorphometric analysis. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes mellitus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HuMSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Regenerative medicine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelwahab AbouBakr Elghareeb , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amr Saad Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamdy Mahmoud Hassanein , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.25.M.Sc.2015.Na.R | 01010110067062000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.25.M.Sc.2015.Na.R | 01020110067062000 | 22.09.2023 | CD - Rom | 67062.CD |