Human platelet alloantigens (HPA-3) and (HPA-5) polymorphism in sickle cell disease patients with vaso-occlusive crisis / (Record no. 53709)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02879cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151203s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2015.Am.H |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amira Salah Farhan |
| 245 10 - TITLE STATEMENT | |
| Title | Human platelet alloantigens (HPA-3) and (HPA-5) polymorphism in sickle cell disease patients with vaso-occlusive crisis / |
| Statement of responsibility, etc. | Amira Salah Farhan ; Supervised Iman Refaat Elmahgoub , Azza Ahmed Ali , Mona Elghamrawy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | في مرضي الانيميا المنجلية الذين يعانون من نوبات إنسداد الاوعية الدموية HPA-3 ,HPA-5 تأثير تعدد الشكل الجيني لجينات ال |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amira Salah Farhan , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 149 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and objectives: Vaso-occlusive crisis (VOC) is a significant cause of morbidity and mortality in sickle cell disease (SCD) patients. Insofar as polymorphism in human platelet antigen (HPA) exhibit a prothrombotic nature, we hypothesized that specific HPA polymorphic variants are associated with VOC. We investigated the distribution of HPA3 and HPA5 alleles genotypes among VOC and non VOC SCD patients. Material &Methods: This study was performed on a total of 100 SCD patients and 50 normal age and sex matched subjects as a control group. Patients were assigned to one of two groups. SCD patients who had VOC events (VOC group; n=60), or SCD patients who reported no such events for the previous 9 months (Steady-state group; n=40). Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Significant higher frequencies of HPA-3b and HPA-5b alleles, were seen in SCD patients than in normal control subjects. Taking homozygous wild-type genotype as reference, univariate analysis identified HPA-3b/3b and HPA-5b/5b to be associated with VOC on comparing the VOC and steady-state groups of patients. Conclusion: The T2622G polymorphism of HPA-3 gene and polymorphism of HPA-5 gene are common among sickle cell disease patients. Neither theHPA-3/ T2622G mutation nor HPA-5/ G1648A mutation is a major determinant of vascularo-cclusion in sickle cell disease patients who are under treatment with hydroxyurea |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Human platlet antigens |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sickle cell disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vascular occlusion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza Ahmed Ali , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Iman Refaat Elmahgoub , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Elghamrawy , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2015.Am.H | 01010110067035000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2015.Am.H | 01020110067035000 | 22.09.2023 | CD - Rom | 67035.CD |