The possible role of aberrant promoter methylation in chronic active hepatitis patients and its relation with interferon therapy response / (Record no. 53837)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03139cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031350.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151208s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2015.Su.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Suzan Hamdy Mohamed Elmasry |
| 245 14 - TITLE STATEMENT | |
| Title | The possible role of aberrant promoter methylation in chronic active hepatitis patients and its relation with interferon therapy response / |
| Statement of responsibility, etc. | Suzan Hamdy Mohamed Elmasry ; Supervised Hamed Abdelfatah Dabaon , Abdelrahman Nabawy Zekri , Mohamed Aly Eldesouky |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور ميثلة البادئ الضال في مرضي الإلتهاب الكبدي الوبائى المزمن النشط و علاقته بالإستجابة للعلاج بالأنترفيرون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Suzan Hamdy Mohamed Elmasry , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 143 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatitis C virus (HCV) is the cause of a significant proportion of cases of chronic liver disease, Hepatocellular carcinoma (HCC) and deaths from liver disease. Egypt has the highest prevalence of HCV worldwide (15%) and the highest prevalence of HCV genotype 4, which is responsible for almost 90% of infections.DNA methylation plays a critical role in the control of important cellular processes and potentiates the progression of HCV related liver disease and affects its response to therapy. Our study aims to show the impact of promoter methylation (PM) of some genes {APC )Adenomatous polyposis coli(, P14ARF, P73, DAPK( Death-associated protein kinase), RASSF1A(Ras-Association Domain Family 1) and O6MGMT(methylguanine-DNA methyltransferase)} on the antiviral response to antiviral therapy and its relation to the presence of fibrosis in HCV-4 infected patients from Egypt. Clinical, laboratory and histopathological data of 53 HCV-4 infected patients who were subjected to combined antiviral therapy were collected; patients were classified according to their response to treatment into: Group I: This group included 24 CH patients non-responded to IFN treatment after 27 weeks positive for HCV infection by RT-PCR. Group II: This group included 29 CH patients responded to IFN treatment after 72 weeks negative for HCV infection by RT-PCR. The main results of this study are the PM of some Tumor Suppressor genes increases in chronic active HCV-4.However, only O6MGMT gene can be used as a predictor of antiviral response and RASSF1A gene as a marker of mild fibrosis grade in the studied patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Adenomatous polyposis coli |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C virus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelrahman Nabawy Zekri, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamed Abdelfatah Dabaon , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Aly Eldesouky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2015.Su.P | 01010110067155000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2015.Su.P | 01020110067155000 | 22.09.2023 | CD - Rom | 67155.CD |