Pharmacological study of the possible anticancer effect of certain drugs in colon cancer cell line / (Record no. 54262)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03144cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031403.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160104s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2015.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mona Magdy Saber Moawad |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacological study of the possible anticancer effect of certain drugs in colon cancer cell line / |
| Statement of responsibility, etc. | Mona Magdy Saber Moawad ; Supervised Afaf A. Ain Shoka , Samia A. Shouman , May A. Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | {uFEA9}{uFEAD}{uFE8D}{uFEB3}{uFE94} {uFEA9}{uFEED}{uFE8D}{uFE8B}{uFEF3}{uFE94} {uFEDF}{uFEE0}{uFE97}{uFE84}{uFE9B}{uFEF3}{uFEAD}{uFE8D}{uFEDF}{uFEE3}{uFEBF}{uFE8E}{uFEA9} {uFEDF}{uFEE0}{uFEB3}{uFEAD}{uFEC1}{uFE8E}{uFEE5} {uFE8D}{uFEDF}{uFEE3}{uFEA3}{uFE97}{uFEE3}{uFEDD} {uFEDF}{uFE91}{uFECC}{uFEBD} {uFE8D}{uFEF7}{uFEA9}{uFEED}{uFEF3}{uFE94} {uFED3}{uFEF0} {uFEA7}{uFEFC}{uFEF3}{uFE8E} {uFE8D}{uFEDF}{uFED8}{uFEED}{uFEDF}{uFEED}{uFEE5} {uFE8D}{uFEDF}{uFEB3}{uFEAD}{uFEC1}{uFE8E}{uFEE7}{uFEF3}{uFE94} |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mona Magdy Saber Moawad , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 171 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The link between inflammation and cancer has been confirmed by the use of anti - inflammatory therapies in cancer prevention and treatment. In{uFB02}ammatory cells and mediators are present in the microenvironment of cancers epidemiologically related or unrelated to in{uFB02}ammatory or infectious conditions. 5 - Aminosalicylic acid (5 - ASA), an anti-inflammatory drug used in the treatment of inflammatory bowel disease, was shown to decrease the growth and survival of colorectal cancer (CRC) cells. Metformin, an oral antidiabetic drug, decreased the incidence of colorectal adenomas in diabetic patients with previous CRC and induced apoptosis in several cancer cell lines. The aim of the present study was to investigate the combinatory effect of 5 - ASA and metformin on proliferation and inflammation - mediated progression of Caco - 2 and HCT - 116 colorectal cancer cell lines. In Caco - 2 and HCT - 116 cells, the expression of pro - inflammatory cytokines was determined by quantitative real time - PCR (qPCR) and the levels of transcription factors of the inflammatory signaling pathways were determined using the ELISA technique. Protein levels of Bax and Bcl - 2 were determined using western blotting and those of matrix metalloproteinase (MMP) - 2 and - 9 by ELISA. Caspase - 3 activity, malondialdehyde (MDA), glutathione (GSH) and nitric oxide contents were measured spectrophotometrically |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colon cancer cell line |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Possible anticancer |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Afaf Abdalmonem Ain Shoka , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | May Ahmad Galal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia Abdalsameeh Shouman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2015.Mo.P | 01010110067469000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2015.Mo.P | 01020110067469000 | 22.09.2023 | CD - Rom | 67469.CD |