Gamma-irradiation and Poly (ADP-ribosylation) in wound healing / (Record no. 54402)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02898cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031407.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160112s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2015.Ta.G |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tarek Ahmed Ali Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Gamma-irradiation and Poly (ADP-ribosylation) in wound healing / |
| Statement of responsibility, etc. | Tarek Ahmed Ali Hassan ; Supervised Ezz Eldeen S. Eldenshary , Mona A. El- Ghazaly , Lázló Virág |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | {uFE8D}{uFEDF}{uFE97}{uFEB7}{uFECC}{uFEF3}{uFECA} {uFE8D}{uFEDF}{uFE9F}{uFE8E}{uFEE3}{uFEF2} {uFEED}{uFE91}{uFEE0}{uFEE3}{uFEAD}{uFE93} {uFE8D}{uFEFB}{uFEF1} {uFEA9}{uFEF1} {uFE91}{uFEF2} {uFEAD}{uFEF3}{uFE91}{uFEED}{uFEAF} {uFED3}{uFEF2} {uFECB}{uFEFC}{uFE9D} {uFE8D}{uFEDF}{uFE9F}{uFEAD}{uFEED}{uFEA1} |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Tarek Ahmed Ali Hassan , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 145 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Wound healing is a complex process involving various cellular and humoral factors. We set out to investigate the role of poly(ADP-ribosyl)ation in wound healing. We found that topically applied PARP inhibitors 3-aminobenzamide and PJ-34 accelerated wound closure in a mouse model of excision wounding. Moreover, wounds also closed faster in PARP-1 knockout mice as compared to wild type littermates. Immunofluorescent staining for poly(ADP-ribose) indicated increased PAR synthesis in scattered cells of the wound bed. Expression of IL-6, TNF-Ü, inducible nitric oxide synthase and matrix metalloproteinase-9 was lower in the wounds of PARP-1 knockout mice as compared to control, whereas expression of IL-1Ý, cyclooxygenase-2, TIMP-1 and -2 were only slightly affected. The level of nitrotyrosine (a marker of nitrating stress) was also lower in the wounds of PARP-1 knockout animals as compared to controls. In vitro scratch assays revealed significantly faster migration of keratinocytes treated with 3-aminobenzamide (3-AB) or PJ34 as compared to control cells. These data suggest that poly (ADP-ribosyl)ation by PARP-1 slows down the wound healing process by increasing the production of inflammatory mediators and nitrating stress and by slowing the migration of keratinocytes. The second part of the study was related to the impact of ionizing on wound healing |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gamma-irradiation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Poly (ADP-ribosylation) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Wound healing |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldeen Saeid Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lázló Virág , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Abdellatif Elghazaly , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2015.Ta.G | 01010110067388000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2015.Ta.G | 01020110067388000 | 22.09.2023 | CD - Rom | 67388.CD |