MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02622cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160113s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2015.Ra.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Raghda Rabe Mohammed Hamed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Pharmaceutical study on certain intranasal drug delivery systems using model drug / |
| Statement of responsibility, etc. |
Raghda Rabe M. Mohammed Hamed ; Supervised Mohamed Farid Elmiligi , Mohamed Ahmed Elnabarawi , Sally Abdelhalim |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسه صيدليه على بعض أنظمه التوصيل الدوائى عبر الأنف بإستخدام نموذج عقار |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Raghda Rabe Mohammed Hamed , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
259 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Betahistine dihydrochloride is indicated for the treatment of vertigo, tinnitus, hearing loss and nausea associated with Ménière's syndrome. Betahistine dihydrochloride is generally given by oral route tablets 16 mg and 24 mg. A mild gastric complaints (e.g. vomiting, gastrointestinal pain, abdominal distension and bloating), have been observed. However, a substantial proportion of patients suffer severe nausea or vomiting during their vertigo attack, which may make oral treatment unsatisfactory. Moreover, betahistine dihydrochloride is highly metabolized primarily by the liver (SERC® product monograph - abbott., 2013). The aim of work in this thesis was to formulate betahistine dihydrochloride in certain nasal dosage forms to provide an alternative dosageforms in order to overcome the drug gastrointestinal disturbance side effects and bypass the liver first pass metabolic effect. The work in this thesis is divided into three chapters namely: Chapter I: Formulation and evaluation of betahistine dihydrochloride nasal Gel delivery system. Chapter II: Formulation and evaluation of betahistine dihydrochloride freeze - dried nasal Insert delivery system. Chapter III: Stability study of Selected Formulations of betahistine dihydrochloride nasal Gel and Insert delivery systems |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Betahistine dihydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Certain intranasal drug delivery systems |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Drug delivery systems |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ahmed Elnabarawi , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Farid Elmiligi , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sally Abdelhalim , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
