MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02137cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160114s2015 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.24.Ph.D.2015.Sh.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shereen Hassan Mohamed Aboul Naga |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Intracellular uptake and storage of bevacizumab in retinal pigment epithelia / |
| Statement of responsibility, etc. |
Shereen Hassan M. Aboul Naga ; Supervised Mahmoud M. Soliman , Johann Roider , Tamer Macky |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
إدخال و تخزين مادة البيفازيزوماب داخل الخلايا الصبغية الطلائية الشبكية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shereen Hassan Mohamed Aboul Naga , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
103 P. : |
| Other physical details |
facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Ophthalmology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Bevacizumab (Avastin®), an anti-VEGF antibody, is used in the treatment of age related macular degeneration, one of the leading causes of legal blindness in the elderly population in the Western world. It was found, that bevacizumab is taken up and stored in vitro in the porcine retinal pigment epithelial (RPE) cells model. In this study, the uptake and intracellular localization of bevacizumab are investigated via immunofluorescence and Western Blot studies, in order to elucidate the underlying mechanism of degradation and storage and possible relevance in vivo. Ultimately, this study attempts to determine the pathophysiology of RPE and bevacizumab interaction and the related pathways, and in combining the data with clinically relevant questions, a better understanding of the function of RPE cells as well as determining potential side effects of anti-VEGF therapy can be reached |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Bevacizumab |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
F-actin cytoskeleton |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
RPE |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Johann Roider , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud M. Soliman , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tamer Macky , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
