Pharmacological study of the possible protective effects of some antioxidants and trace elements on cisplatin-induced nephrotoxicity in rats / (Record no. 54490)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03126cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031409.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160116s2015 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2015.Ka.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kamel Mohamed Kamel |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacological study of the possible protective effects of some antioxidants and trace elements on cisplatin-induced nephrotoxicity in rats / |
| Statement of responsibility, etc. | Kamel Mohamed Kamel ; Supervised Mostafa E. Elsayed , Hekma A. Abdellatif , Salwa A. Metwally |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دوائية للتداخلات المحتملة للتأثيرات الوقائية لبعض مضادات أكسدة و عناصر نادرة علي التسمم الكلوى المحدث بمادة سيسبلاتين في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Kamel Mohamed Kamel , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 243 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Drug-induced nephrotoxicity is an extremely common condition and is responsible for a variety of pathological effects on the kidneys. Cisplatin (CIS), one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side-effects, such as nephrotoxicity and ototoxicity. The present study was performed to elucidate some of the mechanisms involved in the nephroprotective effects of selenium, onion oil, hesperidin and rutin in experimentally cisplatin-induced nephrotoxicity in rats. Cisplatin induced nephrotoxicity was confirmed by elevated serum sodium, total sodium and potassium excreted in urine, serum creatinine, urinary creatinine, BUN, urine volume and relative kidney weight and decreased serum potassium and creatinine clearance. Cisplatin also enhanced caused lipid peroxidation manifested as: decrease in the activity of the antioxidant enzyme (SOD), significant depletion of GSH, enhancement of MDA production in the renal tissue and caused degenerative changes, diffuse acute tubular necrosis, focal inflammatory cells infiltration and focal haemorrhage associated with tubular cast formation. Selenium, onion oil, hesperidin or rutin hampered CIS-induced nephrotoxicity manifested by an enhancement of the glomerular filtration rate which was associated by the reduction of serum sodium, total sodium and potassium excreted in urine, serum creatinine, urinary creatinine, BUN, urine volume and relative kidney weight |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cisplatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nephrotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hekma Abdeltawab Abdellatif , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Elsayed Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Abdelalla Metwally , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2015.Ka.P | 01010110067400000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2015.Ka.P | 01020110067400000 | 22.09.2023 | CD - Rom | 67400.CD |