Role of nicorandil in stem cell modulation in experimentally-induced myocardial damage / (Record no. 54503)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03095cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031410.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160116s2015 ua do f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2015.Sa.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sarah Elsayed Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Role of nicorandil in stem cell modulation in experimentally-induced myocardial damage / |
| Statement of responsibility, etc. | Sarah El-Sayed Mohamed ; Supervised Mahmoud Mohamed Khattab , Lamiaa Ahmed Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة لدور النيكوراندل في تكيّف الخلايا الجذعية في تلف عضلة القلب المحدث تجريبيا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sarah Elsayed Mohamed , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P. : |
| Other physical details | charts , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Methods: ISO was injected subcutaneously for 2 consecutive days at doses of 85 and 170 mg/kg/day, respectively. Nicorandil (3 mg/kg/day) was then given orally with or without a single intravenous injection of BM-MSCs. Electrocardiography and echocardiography were recorded 2 weeks after the beginning of treatment. Rats were then sacrificed and ventricles were isolated for estimation of tumor necrosis factor-alpha, vascular endothelial growth factor and transforming growth factor-beta. Moreover, protein expressions of caspase- 3, connexin- 43 as well as inducible and endothelial nitric oxide synthases were evaluated. Finally, histological studies of myocardial fibrosis and blood vessel density were performed and cryosections were done for estimation cell homing. Results: ISO-induced HF was characterized by significant increase in heart weight index in addition to significant decrease in cardiac conduction and ejection fraction as demonstrated by electrocardiographic and echocardiographic changes. Moreover, myocardial inflammation, fibrosis, apoptosis and angiogenesis were significantly observed. Additionally, myocardial conduction was significantly impaired as estimated by connexin-43 protein expression. Combined nicorandil/BM-MSCs therapy provided an additional improvement compared to cell therapy alone towards reducing ISO-induced cardiac hypertrophy, fibrosis and inflammation. Notably, combined therapy induced significant increase in angiogenesis and cell homing and prevented ISO-induced changes in contractility and apoptotic markers. Conclusion: Combined nicorandil/BM-MSCs therapy was superior to cell therapy alone towards preventing ISO-induced HF in rats through creation of a supportive environment for mesenchymal stem cells |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Heart failure |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Isoprenaline |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mesenchymal stem cells |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Ahmed Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Mohamed Khattab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2015.Sa.R | 01010110067403000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2015.Sa.R | 01020110067403000 | 22.09.2023 | CD - Rom | 67403.CD |