MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02738cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160117s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.13.Ph.D.2015.Ai.O |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Aisha Safwat Seif Eldin |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Oxidative DNA damage and modulation of p53 tumor suppressor gene as possible mechanisms of chromium carcinogenicity / |
| Statement of responsibility, etc. |
Aisha Safwat Seif Eldin ; Supervised Nabil Abdallah Abdelmaksoud , Nermin Hamdy Mohammed , Fatma Mohammed Taha |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التلف التأكسدى للحمض النووى والتحوير الكابت للأورام كآليات ممكنة لسرطنة الكروم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Aisha Safwat Seif Eldin , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
144 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Forensic Medicine -Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Subjects and methods: This work was carried out in twelve small-to medium-sized tanneries, in Misr Al Kadema district in Cairo. The study comprised of two groups, an exposed group (45 male workers) and a matched control group (30 male workers). All workers were subjected to a detailed history including present, past, family and occupational history. Clinical examination was performed with special emphasis on chest and skin examination. Laboratory investigations were performed in the form of kidney function test (blood urea and serum creatinine), blood level of TAC, P53 and chromium. Also, urinary 8-OHdG was done. Results: A significant increase in chromium, p53 and urinary 8-OHG in the exposed group was found with significant decrease of serum TAC compared to their referent control. Significant positive correlation between serum P53 with serum level of TAC. Conclusion: Results revealed that tannery workers have increased level of blood chromium, and this increase is associated with oxidative damage especially oxidative DNA damage reflected by decrease TAC serum level and elevated urinary 8-OHG. Also, up-regulation or activation of serum p53 in tannery workers which was positively correlated with chromium (non-significant) and significantly positively correlated with TAC reinforce the possible relation between oxidative stress induced by chromium exposure and carcinogenesis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
8-OHG and p53 |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chromium |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
TAC |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fatma Mohammed Taha , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nabil AbdAllah AbdelMaksoud , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nermin Hamdy Mohammed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
