MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02813cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160218s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.09.M.Sc.2015.Ya.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yasmin Shokr Mohamed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Role of nitric oxide in experimentally induced liver fibrosis / |
| Statement of responsibility, etc. |
Yasmin Shokr Mohamed ; Supervised Azza M. Agha , Hesham A. Salem , Lamiaa A. Ahmed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
درا{uئإآ٣}{uئإ٩٤} دور أكسيد ا{uئإؤئ}{uئإإ٨}{uئإئ٤}{uئإ٩٨}{uئإءإ}{uئإئ٣}{uئإؤء} {uئإؤ٣}{uئإئ٢} {uئإ٩٧}{uئإإ٠}{uئإئ٤}{uئإؤ٢} ا{uئإؤئ}{uئإؤأ}{uئإ٩٢}{uئإءء} ا{uئإؤئ}{uئإإ٤}{uئإء٤}{uئإءء}ث {uئإ٩٧}{uئإء٠}{uئإءإ}{uئإئ٣}{uئإ٩٢}{uئإئ٤}{uئإ٨إ} |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Yasmin Shokr Mohamed , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
143 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The present study was directed to investigate the possible hepatoprotective effect of nicorandil and to investigate the role of NO donation and KATP channel opening in its possible mediated protection in BDL-induced liver fibrosis in rats. Cholestasis is considered one of the most common causes of liver fibrosis with minimum therapeutic choices. It causes many pathological alterations in liver tissues, which include oxidative stress, inflammation, bile duct proliferation and HSCs activation. HSCs activation leads to proliferation, contractility, fibrogenesis, chemotaxis, matrix deposition and cytokines release. The current investigation included preliminary experiments in order to choose the suitable duration for induction of fibrosis by BDL without nodules formation in addition to the proper hepatoprotective dose of nicorandil and the best time for nicorandil administration. In the present study, BDL was used as a model for cholestasis. Liver fibrosis was induced after 14 days of BDL. The hepatoprotective effect of nicorandil (3mg/kg/day) was investigated in BDL in rats. In order to determine the mechanism by which nicorandil produced its hepatoprotective effect, glibenclamide (10mg/kg/day) or L-NAME (15mg/kg/day) were co-administration with nicorandil in another 2 groups |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Experimentally induced liver fibrosis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Pharmacology and Toxicology |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Role of nitric oxide |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Azza Mounir Agha , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hesham Aly Salem , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lamiaa Ahmed Ahmed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
