MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02564cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160221s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.Ph.D.2015.Sh.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shady Mohammed Abdelhalim |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Fast dissolving systems for an angiotensin receptor blocker / |
| Statement of responsibility, etc. |
Shady Mohammed Abdelhalim ; Supervised Nabaweya Abdelaziz , Omaima Naim Elgazayerly , Maha Mohammed Amin |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
أنظمة سريعة الذوبان لعقار غالق لمستقبلات الأنجيوتنسين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shady Mohammed Abdelhalim , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
267 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
From the obtained results, it was possible to conclude the following: 1. After oral administration of Disartan capsule and LS-SNEDDS formula (A18) with dose equivalent to 30 mg Valsartan/ kg rat, the mean value of the plasma peak concentration (Cpmax) was found to be 8.26 ± 1.24 æg/ml and 14.38 ± 1.45 æg/ml respectively attained after tmax of 1.50 hr. and 0.50 hr. respectively. 2. The bioavailability of Valsartan from LS-SNEDDS relative to Disartan capsule was found to be 218.97 %. 3. The LS-SNEDDS formula (A18), showed extremely significant increase in Cpmax (1.74 fold) and AUC(0-{u221E}) (2.19 fold). 4. The desired enhancement of bioavailability of Valsartan from LS-SNEDDS was achieved via the observed shorter tmax as an indication of absorption rate and increase in the extent of drug absorption as indicated by the area under plasma concentration curve with a percentage relative bioavailability 218.97 %. Finally, LS-SNEDDS succeeded in enhancing Valsartan dissolution more significantly than liquid SNEDDS and S-SNEDDS due to the fact that LS- SNEDDS exhibited lager surface area exposed to the dissolution media. Therefore, the formulation of Valsartan as LS-SNEDDS could be a promising technique in improving its dissolution, bypassing first pass metabolism and thereby its bioavailability |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Angiotensin receptor blocker |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Fast dissolving systems |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pharmaceutics |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maha Mohammed Amin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nabaweya Abdelaziz , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Omaima Naim Elgazayerly , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
