The predictive value of fats (fragile-site associated tumor suppressor) gene expression on the sensitivity of cisplatin in advanced non-small cell lung cancer / (Record no. 55154)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02929cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031429.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160223s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.04.Ph.D.2015.Ah.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Magdy Rabea |
| 245 14 - TITLE STATEMENT | |
| Title | The predictive value of fats (fragile-site associated tumor suppressor) gene expression on the sensitivity of cisplatin in advanced non-small cell lung cancer / |
| Statement of responsibility, etc. | Ahmed Magdy Rabea ; Supervised Rabab Mohamed Gaafar , Ola Mohamed Khorshid , Ayman Abdelsamie Gaber |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى الحالات المتقدمة لسرطان الرئة ذو الخلايا الغير صغيرة المعالجة بعقار السيسبلاتين (Fragile-Site Associated Tumor Suppressor) استخدام الجين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Magdy Rabea , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 132 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Medical Oncology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Patients and methods: A prospective longitudinal study has been conducted in NCI (National Cancer Institute) medical oncology department in outpatient setting, in the period between June 2012 and July 2014. The study included 70 patients with pathologically proven advanced (stage IIIB and IV) non-small cell lung cancer (NSCLC) treated with cisplatin and gemcitabine. FATS gene expression was measured before starting the treatment. The primary end point was overall response rate (ORR) while the secondary end point was progression free survival (PFS) and overall survival (OS).Results: Seventy patients were assessed and included in the trial. Thirteen patients achieved partial response while 13 patients achieved stable disease and the rest had a progressive disease. The overall response rate was statistically significant (p-value 0.031) for the high FATS expression group. The median PFS was 4.1 months (95% CI 2.1-6.2) in the low expression group and 3.8 months (95% CI 3.3-4.3) in the high expression group (p-value 0.442) while median OS was 6.9 months (95% CI 5.4-8.3) in the high expression group and 4.5 months (95% CI 3.7-5.3) in the low expression group (p-value 0.031)Conclusion: The expression of the FATS gene can have an implication on the response to cisplatin and the overall survival. This opens the opportunity that FATS gene can be used as a predictive marker for NSCLC patients receiving cisplatin and gemcitabine chemotherapy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cisplatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FATS |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | NSCLC |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Abdel Samie Gaber , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mohamed Khorshid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rabab Mohamed Gaafar , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.04.Ph.D.2015.Ah.P | 01010110068038000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.04.Ph.D.2015.Ah.P | 01020110068038000 | 22.09.2023 | CD - Rom | 68038.CD |