Expression and mutation frequency of some immunoregulatory genes in mice infected with certain Aspergillus fungal species / (Record no. 55289)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02886cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031434.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160302s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2015.He.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hebatalla Abdelraouf Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Expression and mutation frequency of some immunoregulatory genes in mice infected with certain Aspergillus fungal species / |
| Statement of responsibility, etc. | Hebatalla Abdelraouf Mohamed ; Supervised Mohamed Akmal Elghor , Tahany Mohamed Ali Abdelrahman , Jehane Ibrahim Eid |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التعبير الجينى و معدل الطفرات فى بعض الجينات المنظمة للمناعة فى فئران المعمل المصابة بأنواع معينه من فطر الأسبرجيلس |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hebatalla Abdelraouf Mohamed , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 101 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Invasive pulmonary aspergillosis (IPA) is a lethal complication of persistent neutropenia. In the pathogenesis of IPA, proinflammatory cytokines seem to play a key role. However, little progress has been made in comparing the production of pulmonary cytokines in mice with IPA caused by A. fumigatus and A. flavus at the molecular level. Therefore, the aim was to investigate the mutational and expression pattern of proinflammatory cytokine encoding genes in the lung of immunocompetent and immunocompromised mice infected with either species. The levels of mutational events and transcription of IL-1Ý and IL- 6 encoding genes in the pulmonary tissues of infected mice (with or without immunosuppression) were compared by means of semi-quantitative polymerase chain reaction and PCR-SSCP. Pulmonary fungal burden and histopathological changes were also assessed. The degree of DNA degredation and amounts of pulmonary IL-1Ý and IL-6 induced by A. fumigatus were much higher than those produced by A. flavus. The differential expressions of cytokines by two species were not associated with any mutational events within the selected sequences of the cytokines encoding genes. Our data may explain why A. fumigatus, but less commonly A. flavus, cause IPA and also confirm the contribution of DNA degradation pattern associated with severe inflammation to the pathogenesis of IPA |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | A. flavus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | A. fumigatus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Invasive pulmonary aspergillosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jehane Ibrahim Eid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Akmal Elghor , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tahany Mohamed Ali Abderahman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2015.He.E | 01010110068081000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2015.He.E | 01020110068081000 | 22.09.2023 | CD - Rom | 68081.CD |