MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03120cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160303s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.19.Ph.D.2015.Os.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Osama Ahmed Faried Abdelfattah |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Immunomodulation of the standard treatment of chronic hepatitis C virus infection by probiotic supplement / |
| Statement of responsibility, etc. |
Osama Ahmed Faried Abdelfattah ; Supervised Hala Safouh , Mohamed Abdelhamid , Maissa Elraziky |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التغيرات المناعية الناتجة عن الدعم التكميلى بالبكتيريا النافعة-البروبيوتيك- للعلاج القياسي للإلتهاب الكبدى الفيروسى المزمن سي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Osama Ahmed Faried Abdelfattah , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
152 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Hepatitis C virus (HCV) is a major public health problem and is considered the most common etiology of chronic liver disease in Egypt. Antiviral therapy for HCV infection has improved significantly in recent years and typically includes 24 to 48 weeks of therapy with pegylated interferon Ü (PEG-IFN Ü) and ribavirin; now it is 12-24 with newer therapies. Results from different laboratories, indicate that successful immunity against HCV involves potent T helper 1 (Th1) cellular responses. Several studies indicate that certain probiotic bacteria possess the ability to promote Th1-cell responses. These cells produce IFN-Þ, which has direct antiviral effects.Aim of work: Find out the effect of probiotic bacteria on the cellular immune response of HCV infected patients before and during treatment with pegylated interferon alpha and ribavirin (standard therapy) through testing the effect on IFN-Þ production.Patients and methods: The study was conducted on 60 HCV RNA positive patients who were fit for SOC therapy consisting of Peg-Interferon and Ribavirin. Patients were randomly subcategorized into two main groups, Group 1 (probiotic group) which received the SOC therapy plus probiotic bacteria {u2013} Lactobacillus rhamnosus GG (LGG) ( 30 patients) and Group 2 (placebo group) which received the SOC therapy plus placebo (30 patients).Results: It was found that the levels of IFN-Þ in sera of the placebo and probiotic group patients showed SVR ranging from 36.36 {u2013} 50.02 pg/ml (mean ± SD = 43.19±6.83) and 39.26 - 51.94 pg/ml (mean ± SD = 45.6 ±6.3) respectively . So, there was no statistically significant difference in the IFN-Þ level between placebo and probiotic groups (p value = 0.268) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chronic HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
IFN-Þ |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Probiotics |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hala Safouh , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maissa Elraziky , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Abdelhamid , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
