Expression of TSC genes in the newly diagnosed acute leukemia patients / (Record no. 55483)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02487cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160312s2015 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2015.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mariam Hesham Mahmoud Amer |
| 245 10 - TITLE STATEMENT | |
| Title | Expression of TSC genes in the newly diagnosed acute leukemia patients / |
| Statement of responsibility, etc. | Mariam Hesham Mahmoud Amer ; Supervised Hanaa Hamed Arnaout , Farida Gad Allah , Ola Reda Khorshid |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | لمرضى سرطان الدم الحاد (TSC) معامل الظهور الجيني لجين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mariam Hesham Mahmoud Amer , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 179 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Sixty two Egyptian adult patients suffering from de - novo acute leukemia were assessed for quantitative expression of the TSC1 / TSC2 gene in their bone marrow by real time PCR in addition to other haematological parameters. A control group undergoing bone marrow aspirate for non neoplastic indications were recruited. This study demonstrated that overexpression of the TSC1 / TSC2 complex might be implicated in the process of leukemogensis. In de novo acute leukemia patients TSC1 / TSC2 genes showed higher expression than the control group. In TALL cases there is a statistically significant higher level of expression of TSC1 compared to controls. In BALL and AML patients there is a statistically significant higher expression of TSC2 gene when compared to controls. TSC1 / TSC2 expression did not show any significant correlation to known prognostic indicators (age,leucocytic count and different cytogenetic and molecular markers of the different subgroups). Furthermore patients who achieved complete remission after initial treatment of ALL showed higher levels of TSC1 / TSC2 expression, whereas patients who died in ALL had a high TSC2 expression when compared to controls. Patients who died in the AML group had a higher level of TSC1 when compared to controls |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acute leukemia |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Prognosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TSC1 / TSC2 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Farida Gad Allah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanaa Hamed Arnaout , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Reda Khorshid , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2015.Ma.E | 01010110068236000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2015.Ma.E | 01020110068236000 | 22.09.2023 | CD - Rom | 68236.CD |