MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03251cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160321s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2015.Ay.U |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ayat Salah Eldin Mohamed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Ultrastructural study of extrinsically administered stem cells in response to liver damage and their relation to the microenvironment / |
| Statement of responsibility, etc. |
Ayat Salah Eldin Mohamed ; Supervised Iman Maher Mansour , Lobna Yossif Ghanem , Nelly Abulata |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة فوق خلوية للخلايا الجذعية المزروعة فى حالات الإصابة الكبدية و علاقتها بالبيئة المحيطة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ayat Salah Eldin Mohamed , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
94 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Mesenchymal stem cells transplantation has recently gained widespread enthusiasm particularly in the perspective to use them to treat acute and chronic liver diseases. A stem cell niche is the restricted compartment in a tissue that maintains and regulates stem cell behaviour, supporting self-renewal and maintaining the balance between quiescence, proliferation and differentiation required in response to injury. Accordingly, understanding how the niche influences stem/progenitor cells behaviour is therefore likely to be of scientific and clinical importance if novel strategies are to be developed to promote liver regeneration in the setting of chronic liver injury. Aim of the work: It was intended in this study to determine the behaviour of transplanted stem cells within the liver and to elucidate the interaction of these stem cells with niche cells, soluble factors and the factors that regulate homing of stem cells to the liver during the process of liver injury induced by carbon tetrachloride (CCl4). Materials and Methods: Experimental animal models were designed to identify the behavior of transplanted stem cells in response to liver damage and their relationship to hepatic stem cell niche. Superparamagnetic iron oxide (SPIO) - labeled MSCs were injected into mice in which liver fibrosis by carbon tetrachloride CCl4 was induced. To identify the role of macrophages as one cellular component of the niche, selective hepatic macrophage-depleted animal model subgroup was used using clodronate liposome. Transplanted labeled stem cells are then traced for their homing into their niche and were studied for their differentiation into hepatocytes, neovasculature or myofibroblasts and these activities were correlated with various levels of soluble factors released in the stem cell niche compartment at early and late stages of liver fibrosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chronic liver diseases |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hepatic stem cell niche |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
MSCs |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Iman Maher Mansour , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lobna Yossif Ghanem , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nelly Abulata , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
