MARC details
| 000 -LEADER |
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| fixed length control field |
03457cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160326s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.12.21.M.Sc.2015.Af.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Afaf Saber Mohamed Deab |
| 245 10 - TITLE STATEMENT |
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| Title |
Comparison between baker yeast (Saccharomyces cerevisiae) and L-carnitine in protection and treatment of hepatic toxicity induced by sodium valproate (depakene) as an antiepileptic drug in adult male albino rats / |
| Statement of responsibility, etc. |
Afaf Saber Mohamed Deab ; Supervised Shebl Abdelmonem Shaalan , Amany S. E. Elwakkad , Hanan Mohamed Ebead Saleh |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
مقارنة بين الخميرة والـ - كارنيتين فى حماية وعلاج التسمم الكبدى الناتج من استخدام فالبوريت الصوديوم (الديباكين) كمضاد للصرع فى ذكور الجرذان البيضاء اليافعة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Afaf Saber Mohamed Deab , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
138 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
The liver is the primary organ for drug metabolism and elimination for many antiepileptic drugs (AEDs). The hepatotoxicity induced by antiepileptic drug occurs either because of the production of reactive toxic metabolite(s) or because of induction of immuno-allergic reactions. The aim of this work was to investigate the protective and curative role of L-carnitine and baker yeast (Saccharomyces cerevisiae) against the effect of sodium valproate induced toxicity and oxidative stress in the liver. Materials and Method: Male albino rats (Rattus norvegious) were divided into: Group I (Control): rats received distilled water orally by stomach gavage. Group II (VPA): rats received VPA for six months. Protective main group which subdivided into (B-V), (L-V), (B-L-V) groups and treatment main group which subdivided into (V-B), (V-L), (V-B-L) groups: Physiological studies were investigated using liver function, lipid profile, oxidative stress and histopathological examination. Results: chronic administration of VPA for six months caused a significant increase in AST, ALT, ALP, bilirubin, total lipids, total cholesterol, LDL as well as oxidative stress; MDA and nitric oxide. While decreased total protein, albumin, globulin in addition to glutathione peroxidase and SOD. The administration of L-carnitine and baker yeast in the protective and treatment groups caused significant decreases in the activities of AST, ALT, bilirubin, lipid peroxidation and MDA levels and return the levels of total protein, albumin, globulin, glutathione peroxidase and SOD to the normal levels. In conclusion: L- carnitine and baker yeast (Saccharomyces cerevisiae) offer protection and curative effect to the liver by preserving the structural integrity of hepatocellular membrane against sodium valproate induced hepatotoxicity and oxidative stress |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Baker yeast (Saccharomyces cerevisiae) |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Oxidative stress |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Sodium valproate |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Amany S. E. Elwakkad , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hanan Mohamed Ebead Saleh , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shebl Abdelmonem Shaalan , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Soheir |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
