MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03205cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160405s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.18.Ph.D.2015.Ah.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Ezzat Ahmed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
PNPLA3 and TNF genetic polymorphisms in Egyptian patients with Non alcoholic fatty liver disease / |
| Statement of responsibility, etc. |
Ahmed Ezzat Ahmed ; Supervised Mona Abdelmonem Hegazy , Laila Ahmed Rashed , Abeer Mostafa Elsayed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الأنواع الجينية للبتاتين فوسفوليباز{u٠٦ئ٣} ومعامل التيومر نيكروزيس في المرضى المصريين المصابين بالكبد المتشمع اللاكحولي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ahmed Ezzat Ahmed , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
228 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury in many countries around the world. The histological changes range over a wide spectrum, extending from simple steatosis, which is generally progressive, to non alcoholic steatohepatitis (NASH) which may progress to liver fibrosis, liver cirrhosis, liver cell failure, and sometimes even hepatocellular carcinoma. Liver biopsy is recommended as a gold standard method for the diagnosis and staging of steatosis and fibrosis, and for detecting inflammation in patients with NAFLD. Patatin like phosphlipase and tumor necrosis factor genes (PNPLA3&TNF) plays a key role in modulating metabolism of hepatic triglycerides and consequently magnitude of NAFLD and progression from simple steatosis to NASH with fibrosis. Objectives: To study the effect of Single nucleotide polymorphisms (SNPs) in PNPLA3, and TNF genes on susceptibility to NAFLD and disease progression. Results: There is a definitive association between heterozygous and the non- wild homozygous polymorphisms of Rs738409 PNPLA3, and Rs361525 TNF genes and NAFLD. In NAFLD patients subgroups; the GG genotype of PNPLA3 gene was higher in NASH patient's subgroup while the AA genotype of Rs361525 TNF gene was higher in patients than controls, but we didn{u2019}t reach any significant results in-between the NAFLD patient's subgroups regarding TNF gene. There were a significant difference between NAFLD patients and normal control participants regarding anthropometric measurements, liver enzymes (ALT, AST and GGT), fasting blood sugar and total lipid profile. Conclusion: There was an association between polymorphisms of the studied SNPs of Rs738409 PNPLA3 gene and Rs361525 TNF gene with the incidence of NAFLD and the severity of the disease |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
NAFLD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
PNPLA3 and TNF genes |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
SNPs, |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abeer Mostafa Elsayed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Laila Ahmed Rashed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mona Abdelmonem Hegazy , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Soheir |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
