A Study on the possible therapeutic effects of whey protein products against hepatic fibrosis in experimental rats / (Record no. 55908)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03029cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031452.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160407s2015 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2015.No.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noha Fawzy Hassan |
| 245 12 - TITLE STATEMENT | |
| Title | A Study on the possible therapeutic effects of whey protein products against hepatic fibrosis in experimental rats / |
| Statement of responsibility, etc. | Noha Fawzy Hassan ; Supervised Ezz Eldin Said Eldenshary , Somia A. Nada |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدراسات العلاج{u٠٦أأ}ة المحتملة من منتجات مصل بروت{u٠٦أأ}ن اللبن على التل{u٠٦أأ}ف الكبدى فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noha Fawzy Hassan , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 147 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Inflammation and hepatic stellate cell (HSC) activation are the most crucial steps in the formation of hepatic fibrosis. Hepatocytes damaged by viral or bacterial infection, alcohol or toxic chemicals initiate an inflammatory response that activates collagen production by HSCs. Through this mechanism chronic administration of thioacetamide for 8 weeks at dose (100 mg/kg body weight) effectively induced liver injury and dysfunction and caused hepatic fibrosis. In this study, the effect of Betalactglobulin (Ý-LG), Lacprodan R alpha-10(LAC) and L-methionine were evaluated in TAA-induced hepatic fibrosis in rats. Method: Seventy two Sprague Dawley rats were divided into nine groups. Group 1 received saline only; all groups were injected with TAA two times / week, concurrently, Group3-4 received daily Ý-LG (100mg/kg and 200 mg/kg given orally), respectively.Group 5 received a combination of Ý-LG (50 mg/kg body weight) and l-methionine (40 mg/kg body weight).Groups 6,7 and 8were received the same as groups 3,4 and 5 except we use LAC instead of Ý-LG ,while group 9 was received L-methionine (40 mg/kg body weight) only. Results: TAA induced extensive liver damage that is evidenced by significant increase in serum levels of alanine amino transferase (ALT), Aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin(TB) .Moreover, TAA induced oxidative stress as indicated by significant increase in the hepatic lipid peroxidation (LPO)marker malondialdehyde (MDA) and nitric oxide content(NO) as well as significant decrease in antioxidant enzymes like hepatic reduced glutathione concentration (GSH) and superoxide dismutase (SOD) activities |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatic fibrosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lacprodan-alpha-10 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thioacetamide |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldin Said Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Somia Ahmed Nada , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2015.No.S | 01010110068471000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2015.No.S | 01020110068471000 | 22.09.2023 | CD - Rom | 68471.CD |