Study on topical ocular delivery system of certain non-steroidal Anti-inflammatory drugs / (Record no. 55931)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02931cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031452.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160410s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2015.Ho.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hoda Elsayed Ahmed Teba |
| 245 10 - TITLE STATEMENT | |
| Title | Study on topical ocular delivery system of certain non-steroidal Anti-inflammatory drugs / |
| Statement of responsibility, etc. | Hoda Elsayed Ahmed Teba ; Supervised Nadia M. Morsi , Dalia M. Ghorab , Hanan KM. Refai |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة علي بعض مضادات الإلتهاب في صياغات صيدلية للعين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hoda Elsayed Ahmed Teba , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 308 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aqueous ocular drops of ketorolac tromethamine (KT) are effective and safe for topical use in inhibiting postoperative inflammation of the eyes, reducing postoperative pain, reducing conjunctivitis with no alteration of corneal opacity, and do not increase intraocular pressure. Also, it can be considered as a viable alternative to corticosteroids in treatment of ocular inflammation in the presence of pathogens. Eye drops are favored due to cost advantage, greater simplicity of formulation development and production and the good acceptance by patients despite a little blurring. However, these conventional systems cannot be considered optimal in the treatment of vision-threatening ocular diseases as most of the drugs are washed from the eye and only less than 5% of the administered drugs could penetrate the cornea to reach the desired intraocular tissue due to various mechanisms as lacrimation, tear dilution, and tear turnover. Also, the high frequency of eye drop instillation is associated with patient non-compliance. Polymeric nanoparticles are ranged in size between 10-1000 nm. They are prepared from biocompatible and biodegradable polymers where the drug may be dissolved and entrapped or encapsulated or may be attached to a nanoparticles matrix to achieve controlled drug delivery. Several polymers such as chitosan, alginate and Eudragit have been widely used in pharmaceutical industry for nanoparticles synthesis. Cationic polymers probably have superior mucoadhesiveness due to their ability to develop molecular attraction forces by electrostatic interactions with the negative charges of the mucus |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-inflammatory drugs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aqueous ocular drops |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ketorolac tromethamine (KT) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia M. Ghorab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan KM. Refai , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia M. Morsi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2015.Ho.S | 01010110068474000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2015.Ho.S | 01020110068474000 | 22.09.2023 | CD - Rom | 68474.CD |