Molecular characterization of lovastatin diketide synthase encoding gene in aspergillus terreus / (Record no. 56039)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02747cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031455.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160416s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.05.M.Sc.2015.Ha.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hanan Mohammed Kamal Abdelfatah Osman |
| 245 10 - TITLE STATEMENT | |
| Title | Molecular characterization of lovastatin diketide synthase encoding gene in aspergillus terreus / |
| Statement of responsibility, etc. | Hanan Mohammed Kamal Abdelfatah Osman ; Supervised Mary Sobhy Khalil , Tarek A. A. Moussa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التوصيف الجزيئي للجين المشفرلانزيم المصنع لثنائى الكيتيد لللوفاستاتين فى الاسبرجلس تيريس |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hanan Mohammed Kamal Abdelfatah Osman , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Botany and Microbiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aimed to find a local Aspergillus isolates from the Egyptian soil and air that are capable of producing lovastatin. Lovastatin is one of the natural statins that are used for controlling hyperchlosterolemia, act as a pleotropic drug and also recent researches have shown that lovastatin has promising results for treatment of different types of cancer cells, so 19 Aspergillus isolates were screened for the production of lovastatin using two-stages process of liquid submerged batch fermentation that is consisting of a growth step (seed medium) and a production step (production media) under shaking conditions. Two different seed media and two production media were used for screening; one of them was suitable for production of lovastatin while the other was not, HPLC used for detection of lovastatin in the fungal extracts, 18 isolates out of 19 were capable of production of lovastatin indicating that Aspergillus species may represent a good source for new lovastatin producers, isolate that produced the highest amount of lovastatin (Aspergillus terreus S57) was selected to be identified using molecular biology techniques (ITS region) and to isolate LovF gene (lovastatin diketide synthase encoding gene), which is encoding lovastatin diketide synthase enzyme (LDKS) that is responsible for the conversion of monacolin j to lovastatin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aspergillus |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HPLC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lovastatin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mary Sobhy Khalil , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek Abdelmawgod Abdelelmotalb Moussa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.05.M.Sc.2015.Ha.M | 01010110068546000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.05.M.Sc.2015.Ha.M | 01020110068546000 | 22.09.2023 | CD - Rom | 68546.CD |