MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02583cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160419s2015 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.19.03.Ph.D.2015.Sa.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sally Mahmoud Mohamed Elfishawi |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The effect of killer cell Immunoglobulin - like receptor genotype on Outcome of hematopoietic stem cell transplantation from a matched donor / |
| Statement of responsibility, etc. |
Sally Mahmoud Mohamed Elfishawi ; Supervised Azza Mahmoud Kamel , Alaa Elhaddad , Ghada Ibrahim Mossallam |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير الاختلاف الجينى لمستقبلات الخلايا القاتلة فى نتيجة زرع النخاع العظمى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Sally Mahmoud Mohamed Elfishawi , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
118 P. ; |
| Dimensions |
30cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Successful allogeneic HSCT depends also on T-cell mediated GVL effect, in which donor - derived T cells clear the remaining leukemic cells in patient. In addition to alloreactive T cells, donor - derived natural killer (NK) cells are able to kill malignant or virus-infected cells in the patient. NK cells have a crucial role in relapse prevention by destroying remaining acute myeloid leukemia cells. Natural killer cells are regulated by their surface receptors KIR, which have either activating or inhibitory function by interacting with HLA class I, HLA - C alleles and Bw4 alleles, present on normal cell surface. Fifteen KIR genes can be categorized into inhibitory (KIR A- haplotype) or activating haplotypes (KIR B haplotype) based on their gene content. These haplotypes can be further divided as telomeric and centromeric parts, which contain either A- or B- motifs according to the presence or absence of A- or B- haplotype defining KIR genes. Studies showed that acute myeloid leukemia (AML) patients benefit from the KIR-ligand mismatch due to the 2missing self3 phenomenon. In addition, there is evidence that the risk of relapse is reduced in those AML patients whose donors have several activating KIR genes or KIR - B gene- motifs in unrelated donor HSC |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
HLA |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
HSCT |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
KIR |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Alaa Elhaddad , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Azza Mahmoud Kamel , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ghada Ibrahim Mossallam , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
