MARC details
| 000 -LEADER |
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| fixed length control field |
03340cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160508s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.05.Ph.D.2015.Ra.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Rasha Mohamed Mohamed Hassan |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis and anticonvulsant evaluation of some substituted-1,3-diazaspiro decan-4-one derivatives / |
| Statement of responsibility, etc. |
Rasha Mohamed Mohamed Hassan ; Supervised M. Nabil Youssef Aboul-Enein , Kamilia Mahmoud Amin |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
{uFE97}{uFEB8}{uFBFF}{uFBFF}{uFEAA} و{uئإ٩٧}{uئإؤ٨}{uئآئئ}{uئآئئ}{uئإإ٢} ا{uئإؤئ}{uئإؤ٤}{uئإ٨إ}{uئإأآ}{uئإإ٠}{uئآئئ}{uئإ٩٤} ا{uئإؤئ}{uئإإ٤}{uئإأ٠}{uئإ٨إ}دة {uئإؤئ}{uئإإ٠}{uئإ٩٨}{uئإآ٨}{uئإإ٨}{uئإء٠}{uئإ٨إ}ت {uئإؤئ}{uئإ٩٢}{uئإأأ}{uئإآإ} {uئإإ٣}{uئإآ٨}{uئإ٩٨}{uئإؤ٨}{uئإ٨إ}ت 3,1 داى ازا {uئإآ٣}{uئإ٩٢}{uئآئئ}{uئإءإ}ود{uئآئإ}{uئإؤأ}{uئإ٨إ}ن -4- أون ا{uئإؤئ}{uئإإ٤}{uئإآ٤}{uئإ٩٨}{uئإ٩٢}{uئإءء}{uئإؤئ}{uئإ٩٤} |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Rasha Mohamed Mohamed Hassan , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
158 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The search for anticonvulsant compounds with selective activity and less toxicity continues to be an area of intensive research in medicinal chemistry. Thus, in this work, the first part deals with the synthesis of certain substituted spiroimidazolidinones (1,3-diazaspiro[4.5]decan-4-ones) VIa-d and VIIIa-x and evaluation of their anticonvulsant properties. Also, in this part a molecular modeling study was performed for the designed target compounds. Moreover, in the second part, the enantioseparation of the racemic derivatives VIc-d and VIIIm-x using different polysaccharide type chiral stationary phases (CSPs), namely, Chiralcel OJ, Chiralcel OD and Lux {u2013}amylose-2 has been studied. Accordingly, this thesis is divided into two parts including the following sections: A) Part I Introduction: This part includes the mechanism of action of antiepileptic drugs and a review on the different biological activities of imidazolidines, imidazolidine-2-one and imidazolidine-4-one moieties as well as their methods for synthesis. Aim of the Present Work: This section discusses the rationale on which the design of the synthesized compounds was based, in addition to the schemes followed in their synthesis. Theoretical Discussion: This section addresses the reactions followed in the synthesis of the new target compounds VIa- d and VIIIa-x, in addition to intermediates needed in their preparation. The strategies followed for the synthesis of the designed compounds, as well as starting materials and intermediates have been described in Schemes I and II. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
1,3-diazaspiro |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Anticonvulsant compounds |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Decan-4-one derivatives |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kamilia Mahmoud Amin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
M. Nabil Youssef Aboul-Enein , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
