MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03088cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160518s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.13.Ph.D.2015.Ma.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mai Moustafa Magdi farrage |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Role of micro RNA as marker of liver injury in paracetamol acute toxicity / |
| Statement of responsibility, etc. |
Mai Moustafa Magdi farrage ; Supervised Hala Saied Zaghloul , Abeer Ahmed Zayed , Alaa Mohammed Shehab |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دور الحمض النووي الريبي الدقيق كدلالة علي إصابة الكبد في التسمم الحاد بالباراسيتامول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mai Moustafa Magdi farrage , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
110 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Forensic Medicine and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background & objectives: Paracetamol (acetaminophen) overdose is one of the most common causes of acute liver injury in the world. Early detection of drug induced liver injury remains a problem as the classic markers for liver injury lack clinical sensitivity and specificity. MiRNA 122 & miRNA 192 are promising biomarkers with high sensitivity and specificity for detection of drug induced liver injury. Aim of this study: The aim of the current study is to investigate the potential utility of miRNAs 122 & 192 as markers of human paracetamol-induced liver injury and to compare miRNA with existing biomarkers of liver injury in humans. Results: The age of all participants ranges between 11-57 years with mean age in group (1) 24.83, in group (2) was 23.2 and in group (3) it was 31.07. We found that 100% of cases were suicidal. Males were 21.4% and females were 78.6% of all studied cases. The mean and standard deviation of paracetamol level (mg/l) in group (1) was 287.34±79.74 and in group (2) it was 31.71±12.67. The mean and standard deviation of liver enzymes (AST & ALT) (IU/L) in the study group (1) was in normal range (31.31±2.71 & 20.57±1.96 respectively). The mean and standard deviation of liver enzymes (AST & ALT) in the study group (2) was in range higher than normal limits (91.80±26.93 & 39.29±13.77respectively). Results of paracetamol level, miRNA 122 levels and miRNA 192 levels showed statistical significance between the study group G3 and both groups of cases (groups G1 & G2). Conclusion: Both types of miRNAs included in the study (122 & 192), are highly sensitive markers of paracetamol induced liver injury in cases both with early and late presentation. Keywords: paracetamol, miRNA, RT-PCR, Drug induced liver injury |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
miRNA |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Paracetamol |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
RT-PCR |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abeer Ahmed Zayed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Alaa Mohammed Shehab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hala Saied Zaghloul , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Soheir |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
