MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03341cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160522s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.09.M.Sc.2015.Al.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Alsaeed Abdallah Mohamed Ismaiel |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Study of the possible hepatoprotective effects of nanocurcumin against Zearalenone- induced hepatotoxicity in rats / |
| Statement of responsibility, etc. |
Alsaeed Abdallah Mohamed Ismaiel ; Supervised EZZ Eldin Saeed Eldanshary , Mosaad Attia Abdelwahab , Mohammad Farrag Alyamany |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة الدور الوقائى لمستخلص الكركم المحضر بتقنيه النانو ضد تسمم الكبد الناتج عن الزيرالينون فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Alsaeed Abdallah Mohamed Ismaiel , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
156 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Curcumin has potent anticancer effects in different cancer types. However, the therapeutic applications of curcumin are limited due to its high metabolic instability, poor absorption and bioavailability. Zearalenone (ZEN) is a mycotoxin has hepatotoxic effects and induces adverse liver lesions. The aims of the current study were to prepare curcumin nanoparticles (CurNPs) and to evaluate its protective role against ZER-induced hepatotoxicity in rats. Male Sprague-Dawley rats were divided into 6 treatment groups and treated for 3 weeks as follow: the control group, the groups treated with low dose (100 mg/kg b.w) or high dose (200 mg/kg b.w) of CurNPs and the groups treated with ZEN (40 og/kg b.w.) alone or in combination with CurNPs at the two tested doses. Blood and tissue samples were collected for different biochemical, cytological analyses and histological examination. The prepared CurNPs showed an average size of 100.5 ± 40 nm and negative zeta potential value of 27.5 ± 3.43 mV at natural pH. The results of the biological study revealed that treatment with ZEN alone resulted in a significant increase in liver function parameters, lipid peroxidation (MDA) and DNA fragmentation accompanied with a significant decrease in body weight gain, antioxidant capacity and down regulation of GPX mRNA gene expression as well as severe histological changes in the hepatic tissue. Animals treated with CurNPs at the two tested doses were comparable to the control group. The combined treatment with CurNPs at the two tested doses plus ZEN resulted in a significant improvement in all tested parameters and histological picture of liver tissue in a dose-dependent manner. It could be concluded that CuNPs could overcome the problems associated to the poor solubility of curcumin and succeeded to induce a potential protection against hepatotxicity induced by ZEN mycotoxins |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Curcumin |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Zeralenone |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
EZZ Eldin Saeed Eldanshary , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohammad Farrag Alyamany , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mosaad Attia Abdelwahab , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
