Possible modification of pharmacological effects of pioglitazone by certain antioxidants in metabolic syndrome induced in rats / (Record no. 56587)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03257cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031512.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160522s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2015.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Magy Refaat Nasry |
| 245 10 - TITLE STATEMENT | |
| Title | Possible modification of pharmacological effects of pioglitazone by certain antioxidants in metabolic syndrome induced in rats / |
| Statement of responsibility, etc. | Magy Refaat Nasry ; Supervised Ezz Eldin Eldenshary ,Hala Fahmy Zaki , Amira Mourad Abo-Youssef |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | احتمال تغيير تاثيرات فارماكولوجية للبيوجليتازون باستخدام بعض مضادات الاكسدة فى الجرذان المصابة بمتلازمة الايض |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Magy Refaat Nasry , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 221 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: Incidence of metabolic syndrome (MS) is strongly associated with increased fructose consumption. This study aimed to elucidate the role of pioglitazone, Ü-lipoic acid, hesperidin, caffeic acid and their combinations on fructose-induced MS. Materials and methods: Theriteen groups of rats (n=8) were used. Groups 1-5 were fed on normal diet. First group served as normal control, and the remaining received pioglitazone (2.7 mg/kg), Ü-lipoic acid (100 mg/kg), hesperidin (50 mg/kg) and caffeic acid (20 mg/kg), respectively. Groups 6-13 were fed on fructose-enriched diet (FED) for 15 weeks. The 6th group served as positive control group, and the remaining groups received pioglitazone (2.7 mg/kg), Ü-lipoic acid (100 mg/kg), combination of pioglitazone and Ü-lipoic acid, hesperidin (50 mg/kg), combination of pioglitazone and hesperidin, caffeic acid (20 mg/kg) and combination of pioglitazone and caffeic acid, respectively. Treatments started 10 weeks after the beginning of fructose feeding. At the end of the study, blood and tissue samples were collected for estimation of MS-related markers. Results: Induction of MS was associated with increased weight gain and insulin resistance coupled with elevated levels of blood glucose, insulin, uric acid, urea, creatinine and lipids as well as activities of liver transaminases. FED also reduced glutathione peroxidase activity and total antioxidant capacity, increased nitric oxide and lipid peroxides contents parallel to increased serum levels of leptin and tumor necrosis factor-alpha. Treatment with pioglitazone, Ü-lipoic acid, hesperidin or caffeic acid attenuated most of the changes associated with MS. Besides, combinations of pioglitazone with any of tested agents further improved disease markers |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metabolic syndrome |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pioglitazone |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ü-lipoic acid |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amira Mourad Abo-Youssef , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldin Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2015.Ma.P | 01010110069055000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2015.Ma.P | 01020110069055000 | 22.09.2023 | CD - Rom | 69055.CD |