Possible modification by certain natural products of effects of anti - diabetic drugs in metabolic syndrome in rats / (Record no. 56588)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03257cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031512.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160523s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2015.Re.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reham Abdelrahman Mohammad Elnaggar |
| 245 10 - TITLE STATEMENT | |
| Title | Possible modification by certain natural products of effects of anti - diabetic drugs in metabolic syndrome in rats / |
| Statement of responsibility, etc. | Reham Abdelrahman Mohammad Elnaggar ; Supervised Ezz Eldin Eldenshary , Effat Haroon , Olfat Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إمكانية تغيير فاعلية بعض الأدوية المضادة لمرض السكر باستخدام مواد طبيعية فى الجرذان المصابة بالمتلازمة الأيضية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reham Abdelrahman Mohammad Elnaggar , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 252 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | High intake of dietary fructose is accused for responsibility for the development of the metabolic syndrome (MS). This work aimed to observe the beneficial effect of sitagliptin (Sita), pioglitazone (Pio), alpha lipoic acid (ALA), taurine (Tau) or their combination on fructose-induced MS. Ten groups of rats (n = 12) were fed on fructose enriched diet (FED) for 14 weeks followed by single i.p. injection of streptozotocin (STZ). One served as FED control while the remaining groups received sitagliptin (10 mg / kg. p.o.), pioglitazone (10 mg / kg. p.o.), Ü- lipoic acid (100 mg / kg .p.o.), Taurine (100 mg / kg. p.o.) or their combination, respectively, for the last 4 weeks. A fifth group was fed with on normal diet (normal control). At the end of the study body weight and systolic blood pressure (SBP) were measured, blood samples were collected for estimation of fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance (IR), insulin sensitivity (IS), Ý- cell functions (BCF), triglycerides (TG), total cholesterol (TC), high density lipoproteins cholesterol (HDL - C), low density lipoproteins cholesterol (LDL - C), malondialdehyde (MDA) and uric acid as well as superoxide dismutase (SOD) and glutathione - S - transferase (GST) activities. Induction of MS resulted in significant increases in SBP, FBG, FINS, IR, TG, TC, LDL - C, MDA and uric acid. Meanwhile it resulted in a significant decrease in IS, BCF as well as SOD and GST activities. Treatment of rats with sitagliptin resulted in significant reduction in SBP, hyperglycemia, IR, TG, T. cholesterol, LDL - C, MDA and uric acid levels, as well as improvement in BCF and IS. Similarly, treatment of insulin resistant rats with pioglitazone showed similar results in addition to improvement in serum SOD activity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alpha lipoic acid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sitagliptin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Taurine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Effat Haroon , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ezz Eldin Eldenshary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Shaker , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2015.Re.P | 01010110068961000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2015.Re.P | 01020110068961000 | 22.09.2023 | CD - Rom | 68961.CD |