MARC details
| 000 -LEADER |
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| fixed length control field |
02242cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160524s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.05.M.Sc.2015.Ah.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Ahmed Abbass Mohamed Abdelrahman |
| 245 10 - TITLE STATEMENT |
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| Title |
Synthesis and biological evaluation of certain pyrazole derivatives / |
| Statement of responsibility, etc. |
Ahmed Abbass Mohamed Abdelrahman ; Supervised Fatma Abdelfattah Ragab , Yassin Mohammed Nissan Soliman |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تشييد و تقييم بيولوجى لبعض مركبات البيرازول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ahmed Abbass Mohamed Abdelrahman , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
284 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
The present investigation deals with the semi-synthesis of certain 1,3,4- trisubstituted pyrazole derivatives derived from the natural furochromone khellin, to be screened for their in vivo anti-inflammatory activity and ulcerogenic liability hoping to obtain anti-inflammatory agents with high potency and lower side effects. Furthermore, PGE₂ and TNFÜ immunoassay were carried out to determine the percentage inhibition of these factors by the most active tested compounds. Docking study was conducted for the tested compounds on the active site of COX-2 enzyme to study the binding mode in the active site of the enzyme.The thesis consists of the following parts: 1.Introduction: In this section, literature review about the various biological and pharmacological activities especially the anti-inflammatory activity of pyrazole, pyrazoline, benzofuran and chalcone derivatives was presented. Also, different reported methods for the preparation of both pyrazole and pyrazoline nuclei were described |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Anti-inflammatory activity of pyrazole |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Certain pyrazole derivatives |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Pyrazoles |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Fatma Abdelfattah Ragab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yassin Mohammed Nissan Soliman , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
