A study on the possible role of insulin IGF 1 axis in pre neoplastic inflammation induced in female rats / (Record no. 56635)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03127cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031514.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160525s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.M.Sc.2015.Ne.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Neamat Mahmoud Abdelgilil |
| 245 12 - TITLE STATEMENT | |
| Title | A study on the possible role of insulin IGF 1 axis in pre neoplastic inflammation induced in female rats / |
| Statement of responsibility, etc. | Neamat Mahmoud Abdelgilil ; Supervised Magda Mahmoud Elhamzawy , Omnia Mohamed Abdelmaksod , Heba Samy Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دور الانسولين و عامل النمو المعتمد على الانسولين فى الالتهابات المؤدية الى رحلة ما قبل السرطان فى اناث الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Neamat Mahmoud Abdelgilil , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 251 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The role of insulin and its status are key components in metabolic syndrome. Impressive body of epidemiological data collected over the past decade indicates that a disturbing link may connect the insulin status, to a pre-neoplastic state which may fortell an additional danger: cancer. This evidence also includes studies that examined in particular, the risk of colon cancer or adenoma in relation to some significant determinants of metabolic syndrome related to the insulin IGF 1 axis. Thus, the present study aimed to further explore the possible role of insulin, IGF-1 axis in modulating the pathogenic events related to the low grade chronic pre-neoplastic inflammation induced experimentally in the colon of a diabetic female rat model. To achieve this aim, two experimental diabetic models were induced. The first experimental model was applied to a group of female rats to induce hyperinsulinemia (T2DM) by keeping them on a diet of high glycemic value ad lipidum. The second was induced on a second group of animals to induce a state of hypoinsulinemia (T1DM) by giving them a single dose of streptozotocin. Study groups included: a control group representing the vehicle treated rats (Group I) and two main experimental groups: T2DM (Group II) and T1DM (Group III). All animals were left for a study period of 8 weeks. Four weeks before the termination of the study period, the animals of the three groups were further divided into 2 subgroups: the A subgroups (IA, IIA, IIIA) were slowly infused with a single dose of saline into the distal colon, the B subgroups (IB, IIB, IIIB) were subjected to a single intracolonic dose infusion of 4% acetic acid solution |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Insulin IGF 1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Samy Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magda Mahmoud Elhamzawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omnia Mohamed Abdelmaksod , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.M.Sc.2015.Ne.S | 01010110068985000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.M.Sc.2015.Ne.S | 01020110068985000 | 22.09.2023 | CD - Rom | 68985.CD |