GSTP1 gene mutation as a risk factor for development of M2 and M4 subtypes of acute myeloid Leukemia / (Record no. 57005)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02865cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031524.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160622s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2016.Sa.G |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Safa Nabil Abdelfattah Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | GSTP1 gene mutation as a risk factor for development of M2 and M4 subtypes of acute myeloid Leukemia / |
| Statement of responsibility, etc. | Safa Nabil Abdelfattah Mohamed ; Supervised Hoda Ali Sadek , Shadia Hassan Ragab , Mosaad Mahmoud Eegammal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | من سرطان الدم الميلودى الحاد M4و M2كعامل يعرض لخطر نشئة نوعى GSTP1طفرة جين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Safa Nabil Abdelfattah Mohamed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 169 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Glutathione S-tansfeases comprise a family of phase II detoxification enzymes involved in the metabolism of many environmental carcinogens, drugs & other xenobiotics. GSTP1 gene (I105V) mutation alters the protein function, diminishing its detoxification ability for certain mutagens and carcinogens which could result in increased DNA damage & an increased risk of leukaemogenesis. In our study we aimed to clarify the relation between GSTP1 gene (I105V) mutation and the risk of M2 & M4-AML. We also studied the relation between GSTP1 genotypes and the clinical presentations, hematological findings and treatment response in AML cases. We analyzed the presence of this mutation in 100 de novo M2 & M4-AML patients and 100 age & sex matched controls, using PCR-based restriction fragment length polymorphism (PCR-RFLP) technique. Our study suggests that individuals with at least one GSTP1 codon 105 Val allele are at a significantly high risk of developing M2 and M4 subtypes of AML. We also found a significant elevation of the valine allele among the M4 cases compared to M2 cases. GSTP1 polymorphism was associated with a higher platelet count and a lower bleeding tendency on clinical basis in M2 and M4-AML patients. Also the GSTP1 mutant genotypes were associated with more induction related mortality and less complete remission rates. Hence the present study suggests that GSTP1 Ile105Val polymorphism might influence M2 and M4-AML development, progression and response to therapy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AML |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GSTP1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mutation |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoda Ali Sadek , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mosaad Mahmoud Elgammal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shadia Hassan Ragab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2016.Sa.G | 01010110069334000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2016.Sa.G | 01020110069334000 | 22.09.2023 | CD - Rom | 69334.CD |