MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03045cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160625s2015 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.21.M.Sc.2015.Ba.T |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Basant Fawzy Awad Abdelsalam |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Toxicokinetics and toxicodynamics of acetone in male albino rats / |
| Statement of responsibility, etc. |
Basant Fawzy Awad Abdelsalam ; Supervised Kawther S. AbouElala , Gamal M. Morsy , Ahmed Mohamed Shehata |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الحركة السمية و الديناميكية للأسيتون فى ذكور الجرذان البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Basant Fawzy Awad Abdelsalam , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
114 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The present study aims to evaluate the lethality, residue, toxicokinetics and toxicodynamics of acetone in serum of male albino rats as a mammalian model. The lethality percentile doses (LDs): LD₁ to LD₉₉ of acetone at 24 hours were estimated after oral-intubation with acetone. The computed LD₅, LD₃₀ and LD₅₀ were 1.3, 3.0 and 4.6 g / kg b. wt., respectively. Three groups of male albino rats were orally-intubated with a single dose of 0g (group 1: control), LD₅ (group 2) and LD₃₀ (group 3) of acetone / kg b. wt. Statistically, the acetone residue in serum of rats of groups 1, 2 and 3 and the areas under curves (AUC and AUC {u0368} {u0367} {u036B} ) and areas under moment curves (AUMC and AUMC {u0368} {u0367} {u036B} ) in serum of rats of groups 2 and 3 were significantly affected by the experimental periods (1, 6, 12, 24 and 48 hours), intubated doses (0, 1.3 and 3.0 g) and their interactions. The acetone residue in serum of rats of groups 2 and 3 showed a negative exponential relationship with the experimental periods with correlation coefficients (r) - 0.95 and - 0.72, respectively. In comparison with rats of group 2, the AUC total AUMC total, half- life of elimination (T ¹ {u2044} ₂), the mean retention time (MRT) of acetone in serum of rats of group 3 were significantly increased, whereas the total clearance (CL) and the elimination rate constant (Lz) were markedly decreased at all the experimental periods. The levels of glucose, urea, total lipids, triglycerides, ii cholesterol and AST activities in serum of rats of groups 1, 2 and 3 were significantly affected by the experimental time, doses of acetone and their interactions. In conclusion, the toxicokinetics and toxicodynamics of acetone in serum of mammals were time and dose- dependent. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Acetone |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Male albino rats |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Toxicokinetics and toxicodynamics |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Mohamed Shehata , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gamal Mohamed Morsy , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kawther Sayed AbouElala , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
