A study of the possible neuroprotective effects of simvastatin and curcumin in l-methionine-induced vascular dementia in rats / (Record no. 57087)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02925cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031527.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170103s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2016.Ah.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mohamed Eldesoky Youssef |
| 245 12 - TITLE STATEMENT | |
| Title | A study of the possible neuroprotective effects of simvastatin and curcumin in l-methionine-induced vascular dementia in rats / |
| Statement of responsibility, etc. | Ahmed Mohamed El Desoky Youssef ; Supervised Hala Fahmy Zaki , Azza Sayed Awad , May A. Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة لتأثيرات الوقاية العصبية المحتملة لكل من سيمفاستاتين و الكركمين في الخرف الوعائي الذي يسببه ل-ميثيونين في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Mohamed Eldesoky Youssef , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 212 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Vascular dementia (VaD) is a degenerative cerebrovascular disorder that leads to progressive decline in cognitive abilities and memory. Several reports demonstrated that oxidative stress and endothelial dysfunction are principal pathogenic factors in VaD. The present study was constructed to determine the possible neuroprotective effects of simvastatin and curcumin in comparison with cilostazol in VaD induced by l-methionine in rats. Male Wistar rats were divided into five groups. Group I (control group), group II received l-methionine (1.7g/kg, p.o.) for 32 days. The remaining three groups received simvastatin (50 mg/kg, p.o.), curcumin (300mg/kg, p.o.) and cilostazol (100 mg/kg, p.o.), respectively for 32 days after induction of VaD by l-methionine. Subsequently, rats were tested for cognitive performance using Morris water maze test then sacrificed for biochemical and histopathological assays. L-methionine induced VaD reflected by alterations in rats' behavior as well as the estimated neurotransmitters, acetylcholinesterase activity, as well as, increased brain oxidative stress and inflammation parallel to histopathological changes in brain tissue. Treatment of rats with simvastatin or curcumin ameliorated l-methionine-induced behavioral, neurochemical and histological changes in a manner comparable to cilostazol. Simvastatin or curcumin may be regarded as a potential therapeutic strategy for the treatment of VaD |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | L-methionine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Simvastatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vascular dementia |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Azza Sayed Awad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Fahmy Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | May Ahmed Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2016.Ah.S | 01010110069345000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2016.Ah.S | 01020110069345000 | 22.09.2023 | CD - Rom | 69345.CD |