MARC details
| 000 -LEADER |
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| fixed length control field |
03279cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
160711s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.11.29.M.Sc.2015.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Marwa Mostafa Awad |
| 245 10 - TITLE STATEMENT |
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| Title |
Effect of lisinopril, ramipril and their combinations with aspirin on systemic hypertension and hemostatic profile in albino rats / |
| Statement of responsibility, etc. |
Marwa Mostafa Awad ; Supervised Maha Moufid Mashaly , Amani Nabil Shafik , Lubna Omar Elfarouk Abdelsalam |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثيرليزينوبريل: راميبريل و جمعهما مع الأسبرين على ارتفاع ضغط الدم و بيان تخثر الدم فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Marwa Mostafa Awad , |
| Date of publication, distribution, etc. |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
196 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Hypertension is a major risk factor of high prevalence worldwide for cardiovascular disease. Impaired endothelial function is intimately associated with the development of hypertension and atherosclerosis. Angiotensin - converting enzyme inhibitors are extensively used to improve clinical outcome of patients with several cardiovascular diseases. We attempt a comparative study of drug-drug interaction between two different subtypes of angiotensin enzyme inhibitors, lisinopril and ramipril when combined with aspirin carried out on L - nitro arginine methyl ester (L - NAME) - induced hypertension in rats. The effect of this drug combination was tested on the reversal of endothelial dysfunction and on coagulation profile. The drugs were given P. O. for 4- weeks, lisinopril and ramipril were given in a dose of 20 mg/kg/day, while aspirin was given in a dose of 5 mg/kg/day. The selected drugs were given simultaneously with L - NAME 60 mg/kg/day orally. The systolic blood pressure was monitored by weekly-measurement of blood pressure by non-invasive tail cuff technique. The effect on endothelial dysfunction was estimated pharmacologically by vascular reactivity studies on isolated aortic rings in vitro. Histopathological examination of the heart using hematoxylin and eosin and Masson trichrome stain was done to assess the degree of myocardial fibrosis. Coagulation profile was assessed by the bleeding time test and the prothrombin time. Our study revealed that both lisinopril and ramipril decreased the systolic blood pressure significantly compared to L - NAME with insignificant difference between them in all measurements. Ramipril showed marked improvement of endothelial reactivity and cardiac fibrosis compared to lisinopril. Pronounced prolongation in bleeding time and prothrombin time with the tissue ACEI ramipril and its combination with aspirin compared with the plasma ACEI lisinopril |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Endothelial dysfunction |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Hypertension |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
L - NAME |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Amani Nabil Shafik , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lubna Omar Elfarouk Abdelsalam , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maha Moufid Mashaly , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
