Pathological and clinicopathological studies on nano technology as a tool for treatment of diethylnitrosamine-induced hepatic affections in albino rats / (Record no. 57213)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03447cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031530.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160724s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.05.Ph.D.2016.Em.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Eman Ibrahim Hassanen Ibrahim |
| 245 10 - TITLE STATEMENT | |
| Title | Pathological and clinicopathological studies on nano technology as a tool for treatment of diethylnitrosamine-induced hepatic affections in albino rats / |
| Statement of responsibility, etc. | Eman Ibrahim Hassanen Ibrahim ; Supervised Adel Mohammed Bakeer , Reda Mohammed Sayed , Taher Ahmed Salah Elden |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات باثولوجية و كلينيكوباثولوجية على تكنولوجيا النانو كوسيلة لعلاج بعض التأثيرات المرضية الكبدية التى يحدثها ثنائى الايثيل نيتروسامين فى الجرزان البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Eman Ibrahim Hassanen Ibrahim , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 195 P. |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study was designed to perform the ability of gold nanoparticles (GNPs) to improve the hepatotherapeutic effect of cisplatin against diethylnitrosamine (DENA)-induced Hepatocarcinogenicity with minimal side effect. 13nm sized GNPs were prepared by citrate reduction method and conjugated by cisplatin, and then the prepared particles were characterized by using U.V. spectrophotometer, TEM and Zetasizer nano. The experiment was carried out on 120 male albino Wister rats (average b.wt 70-100g). The animals were divided into 2 groups, group (A) kept as negative control and group (B) received DENA and CCL4. Each group was subdivided into 7 subgroups according to different methods of treatments. Concerning group (B) the 1st group received DENA and CCL4 then kept as positive control. The 2nd and 3rd group received DENA and CCL4 then treated by cisplatin for short and long period respectively. The 4th and 5th group received DENA and CCL4 then treated by GNPs for short and long period respectively. The 6th and 7th group received DENA and CCL4 then treated by GNPs-cisplatin conjugates for short and long period respectively. Group (A) treated with the same methods as in positive control groups. Then recording the clinical signs, body and tissue weights, clinical biochemical parameters (ALT, AST, ALP, T.Bil., D.Bil. and GGT), liver oxidative stress markers (MDA, GSH and CAT) as well as gross lesions, histopathological lesions of liver and kidneys and immunohistochemical staining of liver tissues were done. GNPs residues were determined in different organs by using ICP-MS to study the biodistribution of GNPs. The results of this study revealed the antioxidant and hepatotherapeutic effect of nontoxic GNPs against DENA-induced hepatocarcinogenicity and also confirmed the detoxification of cisplatin by GNPs |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cisplatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diethylnitrosamine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gold nanoparticles |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Adel Mohammed Bakeer , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reda Mohammed Sayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taher Ahmed Salah Elden , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.05.Ph.D.2016.Em.P | 01010110069477000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.05.Ph.D.2016.Em.P | 01020110069477000 | 22.09.2023 | CD - Rom | 69477.CD |