MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03017cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
160730s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.01.Ph.D.2016.He.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hebatullah Samy Mohamed Helmy |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Comparative study of the effect of certain antitumor drugs on neoplastic transformations of rats liver / |
| Statement of responsibility, etc. |
Hebatullah Samy Mohamed Helmy ; Supervised Tarek Mohamed Kamal Motawi , Noha Ahmed Elboghdady , Abeer Moustafa Elsayed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة مقارنة لتأثير بعض الأدوية المضادة للسرطان علي التحول السرطاني في كبد الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Hebatullah Samy Mohamed Helmy , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
122 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) possess tumor initiating, metastatic and drug resistance properties. This study was conducted to evaluate the effect of pegylated interferon-Ü2a (PEG-IFN-Ü2a) and 5-fluorouracil (5-FU) on the expression of CSCs markers and on specific pathways that contribute to the propagation of CSCs in HCC. HCC was initiated in rats using a single intraperitoneal dose of diethylnitrosamine (DENA) (200 mg/kg) and promoted by weekly subcutaneous injections of carbon tetrachloride (CCl4) for six weeks. After the appearance of dysplastic nodules, the animals received either PEG-IFN-Ü2a or 5-FU for eight weeks. CSCs markers (OV6, CD90) and molecules related to transforming growth factor-Ý (TGF-Ý) and other signaling pathways were assessed in hepatic tissues. PEG-IFN-Ü2a treatment effectively suppressed the hepatic expression of OV6 and CD90, ameliorated the diminished hepatic expression of TGF-Ý receptor II (TGF-ÝRII) and Ý2 spectrin (Ý2SP) and significantly reduced the elevated hepatic expression of TGF-Ý1, interleukin6 (IL6), signal transducer and activator of transcription3 (STAT3) and vascular endothelial growth factor (VEGF). In contrast, 5-FU treatment failed to reduce the over-expression of CSCs markers and barely affected the disrupted TGF-Ý signaling. Furthermore, it had no effect on angiogenesis or nitrosative stress. In conclusion, PEG-IFN-Ü2a, but not 5-FU, could reduce the propagation of CSCs during the progression of HCC by upregulating the disrupted TGF-Ý signaling, suppressing the IL6/STAT3 pathway and reducing angiogenesis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
5-fluorouracil |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pegylated interferon-Ü2a |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abeer Moustafa Elsayed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Noha Ahmed Elboghdady , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tarek Mohamed Kamal Motawi , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
