The potential therapeutic effect of Origanum majorana extract against hepatorenal toxicity induced by cisplatin in male albino rats / (Record no. 57681)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03252cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031544.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160907s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2016.Sh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shreen Desokey Abdelhamed |
| 245 14 - TITLE STATEMENT | |
| Title | The potential therapeutic effect of Origanum majorana extract against hepatorenal toxicity induced by cisplatin in male albino rats / |
| Statement of responsibility, etc. | Shreen Desokey Abdelhamed ; Supervised Mohamed Marzouk Mohamed , Amel Mahmoud Soliman , Amany Ahmed Sayed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير العلاجي المحتمل لمستخلص البردقوش ضد السمية الكبدية الكلوية المستحثة بالسيسبلاتين في ذكور الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shreen Desokey Abdelhamed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 167 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cisplatin (CDDP) is a widely potent anticancer drug used in chemotherapy, unfortunately it elicits major undesirable side effects in various tissues, including liver and kidney. The aim of the present study was to investigate whether Origanum majorana ethanolic extract (OMEE) can reduce cisplatin-induced hepatorenal toxicity. The effectiveness of OMEE was compared with silymarin as a standard hepatoprotective drug. Male albino rats were divided into four groups (6 rats/group). Rats of the control group were administered distilled water for 17 consecutive days. The rest of rats were received a single intraperitoneal injection of CDDP (3 mg/kg body weight), then after 3 days, rats were administered orally for 14 days distilled water (CDDP group) or OMEE (500 mg/kg/day) (OMEE group) or silymarin (150 mg/kg/day). CDDP-induced hepatorenal toxicity was assessed biochemically by an increase in levels of serum ASAT, ALAT, ÞGT, LDH, ALP, total bilirubin, creatinine, urea, uric acid, BUN, total lipid, triglycerides and LDL-cholesterol. In addition, a decrease in serum total protein, albumin and HDL-cholesterol concentrations was recorded in comparison with the control group. Meanwhile, CDDP-induced an oxidative stress, which evidenced by a significant increase in hepatic and renal MDA, NO levels as well as a significant reduction in hepatic and renal GSH, SOD, GST and CAT contents as compared to the corresponding one of control group. Liver and kidney histopathological changes were observed in the cisplatin group as compared to the control group. Interestingly, oral administration of OMEE or silymarin significantly ameliorates the abnormal effects of CDDP on nearly all the studied parameters |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cisplatin-hepatorenal toxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Originum majorana ethanolic extract |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Ahmed Sayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amel Mahmoud Soliman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Marzouk Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2016.Sh.P | 01010110069666000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2016.Sh.P | 01020110069666000 | 22.09.2023 | CD - Rom | 69666.CD |