A study of toll like receptor-7 single nucleotide polymorphisms in systemic lupus erythematosus patients / (Record no. 57740)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02859cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031546.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160918s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2015.La.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lamees Ahmed Samy |
| 245 12 - TITLE STATEMENT | |
| Title | A study of toll like receptor-7 single nucleotide polymorphisms in systemic lupus erythematosus patients / |
| Statement of responsibility, etc. | Lamees Ahmed Samy ; Supervised Inas Ismail Raafat , Nancy Mohammed Elguindy , Rasha Mohammed Hosny Shahin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة عن التعدد الشكلى لجين المستقبل شبيه التول -7 فى مرضى الذئبة الحمراء المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Lamees Ahmed Samy , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 197 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the development of an immune response directed against any part of the host body.The aim of the study is to analyze the association between TLR7 gene polymorphisms and systemic lupus erythematosus susceptibility and its association with various clinical and laboratory data of the patients. In this study genotyping of Toll like receptor gene-7rs (3853839) by real time Polymerase Chain Reaction Allelic discrimination revealed that, the wild genotype of TLR7 gene rs (3853839) (CC genotype) was detected in 20/50 (40%) of cases, and in 33/50(66%) of the controls. The minor genotypes of TLR7gene rs(3853839) (CG & GG genotypes) were detected in 26/50 (52%) and 4/50(8%) of cases respectively, and in 6/50 (12%) and 11/50 (22%) of the controls respectively. A statistical significant difference could be elicited between the two groups as regards genotyping distribution P value =0.001 The SLE patients were classified according to the different TLR7 rs (3853839) genotypes into 2 distinct groups: the wild (C/C) genotype group which included 20 patients, the polymorphic (C/G, G/G) genotypes group which included 30 patients. These 2 groups were compared as regards clinical and laboratory data: There was no statistical significance between both groups. While Comparison between the 2 groups revealed a statistically significant difference as regarding the presence of nephritis p value= 0.021 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SLE |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SNPs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TLR |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Inas Ismail Raafat , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nancy Mohammed Elguindy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rasha Mohammed Hosny Shahin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2015.La.S | 01010110069546000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2015.La.S | 01020110069546000 | 22.09.2023 | CD - Rom | 69546.CD |