Fibronectin gene polymorphisms in HCV related type II mixed cryoglobulinemia: risk of development of B-cell lymphoma / (Record no. 57741)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03174cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031546.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160918s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2016.Ra.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rabab fouad Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Fibronectin gene polymorphisms in HCV related type II mixed cryoglobulinemia: risk of development of B-cell lymphoma / |
| Statement of responsibility, etc. | Rabab fouad Mohamed ; Supervised Hala Farawela , Nariman M. Zahran , Bothaina Madkour |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تعدد أشكال جين فيبرونكتن و مخاطر الأصابة بالليمفوما في مرضى الكريوجلوبولينيميا المختلطة في حالات مصابة بفيروس سي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rabab fouad Mohamed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 172 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | NHLs are clonal malignancies with diverse clinical presentations, pathogenesis and biologic behavior. It results from accumulation of genetic insults that lead to unregulated lymphocyte proliferation. Malignant lymphocytes usually accumulate in lymph nodes and cause the characteristic clinical feature of lymphadenopathy. HCV is a major cause of liver-related morbidity and is increasingly recognized as an instigator of B-cell lymphoproliferative disorders such as mixed cryoglobulinemia and non-Hodgkin lymphoma. Fibronectin is a multifunctional glycoprotein of 250 kDa which is encoded by a gene of over 75 kb in length, located on chromosome 2q34{u2013}36 and composed of 50 exons. The purpose of the current study was to investigate the possible relationship between two FN polymorphisms (called MspI and HaeIIIb) and the development of lymphoma in HCV positive patients with mixed cryoglobulinemic syndrome compared to healthy age and sex matched individuals. The present study included 75 patients; 25 HCV positive patients with MCns and 50 NHL patients, in addition to 25 healthy controls. To achieve this aim, genotyping for FN gene was done by PCR- RFLP technique and screening for HCV infection was performed by ELISA and confirmed by RT-PCR, cryoglobulins were detected by cold precipitation (4{u00B0}C for 72{u2013} 96 h) and plasma FN levels were assessed by ELISA. The study revealed that HaeIII-AB genotype can be considered as a risk factor for NHL development and high HaeIII-A allele frequency seems to be linked to NHL development. It was also found that plasma FN level did not show any significant difference between NHL patients and each of HCV positive patients with MCns and controls |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | FN gene polymorphisms |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCV |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | NHL |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bothaina Madkour , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Farawela , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nariman Mohamed Zahran , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2016.Ra.F | 01010110069684000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2016.Ra.F | 01020110069684000 | 22.09.2023 | CD - Rom | 69684.CD |