Comparative study on the effect of different adjuvants on the immunogenicity of hepatitis B vaccine / (Record no. 57754)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02980cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031547.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160918s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.06.M.Sc.2016.No.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nourhan Hassan Abdelallah |
| 245 10 - TITLE STATEMENT | |
| Title | Comparative study on the effect of different adjuvants on the immunogenicity of hepatitis B vaccine / |
| Statement of responsibility, etc. | Nourhan Hassan Abdelallah ; Supervised Magdy Ali Amin , Hossam Mohamed Ashour , Abeer A. Halim Boseila |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مقارنة عن تأثير المواد المساعدة المختلفة على النشاط المناعى من لقاح التهاب الكبد الوبائي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nourhan Hassan Abdelallah , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 97 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The best way to prevent hepatitis B is by getting the hepatitis B vaccine. Although the current Hepatitis B vaccine, which contain alum is safe and generally efficacious, still provides some limitations which hinder the goals of controlling the disease worldwide. These trigger the efforts to improve vaccine immunogenicity by developing new adjuvant. In this present study we evaluated the use of Chitosan (Ch), Sodium alginate (S) as safe, nature and effective adjuvant to hepatitis B antigen (HBsAg) alone or combined with alum (Al) by preparing different formulations of Hepatitis B vaccine that were administrated subcutaneously to mice. After 28 days post-immunization, rate of seroconversion, serum HBsAg-specific antibody titers and IL-4, IFN-Þ levels were evaluated. The results showed that Ch and S groups exhibited comparable immunogenic effect as Al group and unadjuvanted group; Moreover Ch group elicited a balanced Th1/Th2 response, while S group shifted the response toward a Th2 pathway. The highest immunogenic response was observed in AlChS group with the highest seroconversion rate, anti-HBsAg IgG titer, IL-4 and IFN-Þ enhancement production, significantly higher than the entire immunized group, while other combined adjuvanted formulations AlCh, AlS gave no additional important benefits. These findings indicated that both Chitosan and Sodium alginate could be a safe and effective adjuvant for Hepatitis B vaccine inducing 10-fold immunogenic response than the same dose of unadjuvanted antigen whether used alone or in combination with Alum |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Adjuvant |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis B |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vaccine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Abdelhalim Boseila , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hossam Mohamed Ashour , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ali Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.06.M.Sc.2016.No.C | 01010110069557000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.06.M.Sc.2016.No.C | 01020110069557000 | 22.09.2023 | CD - Rom | 69557.CD |