Impact of mesenchymal stem cells and vitamin d on transforming growth factor beta signaling pathway of hepatocellular carcinoma in rats / (Record no. 57765)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03017cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031547.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160919s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.Ph.D.2016.Sh.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shaimaa Saad Eldin Mohammad |
| 245 10 - TITLE STATEMENT | |
| Title | Impact of mesenchymal stem cells and vitamin d on transforming growth factor beta signaling pathway of hepatocellular carcinoma in rats / |
| Statement of responsibility, etc. | Shaimaa Saad Eldin Mohammad ; Supervised Hanan Hassan Fouad , Laila Ahmed Rashed , Soheir Mahfouz |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير الخلايا الجذعية وفيتامين د علي طريق إشارات معامل نمو التحول بيتا في جرذان التجارب البيضاء المصابة بسرطان الكبد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shaimaa Saad Eldin Mohammad , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 190 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatocarcinogenesis is a complex and multi-step process resulting from a combination of epigenetic and genetic alterations. Transforming growth factor-beta (TGF-Ý) signaling pathway has been recognized as a key driver in cancer, where its activation affects cell proliferation, angiogenesis, invasion and metastasis. We evaluated the effect of mesenchymal stem cells (MSCs) and vitamin D on TGF-Ý signaling in hepatocellular carcinoma (HCC), in vivo, on hepatoma induced animal model in rats. Also we investigated the effect of MSCs and vitamin D, in vitro, on hepatoma cell line (HepG2 cells). Results: TGF-Ý level and the gene expression of TGF-Ý downstream target genes (Smad3 and snail), in addition to Smad2 protein level in rat liver tissues were downregulated in all treated groups with more suppressive effect in the group treated with both MSCs and vitamin D. Serum levels of AFP and ALT were significantly decreased in all treated groups. Also, all treated HepG2 cells showed a significant increase in Bax and significant decrease in Bcl-2 gene expression, in addition to significant decrease in HepG2 cell proliferation rate. Histopathological examination of liver tissue from induced HCC rats which received DENA-CCl4 only, revealed dysplastic cirrhotic nodules and solid areas of neoplasia. Administration of MSCs or vitamin D into induced HCC rats improved the histopathological picture with residual pathology, while administration of both MSCs and vitamin D showed restoration of liver parenchyma |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TGF-Ý signaling |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Hassan Fouad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Mahfouz , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.Ph.D.2016.Sh.I | 01010110069689000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.Ph.D.2016.Sh.I | 01020110069689000 | 22.09.2023 | CD - Rom | 69689.CD |