Effect of vitamin D supplementation on cardiac contractility in diabetic rats / (Record no. 57769)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03083cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031547.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160919s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.M.Sc.2016.Do.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Doaa Mostafa Elsayed |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of vitamin D supplementation on cardiac contractility in diabetic rats / |
| Statement of responsibility, etc. | Doaa Mostafa Elsayed ; Supervised Samah Elattar , Nashwa Eltablawy , Shaimaa Nasr Amin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تاثير فيتامين د على انقباض عضلة القلب فى الفئران المصابة بمرض السكر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Doaa Mostafa Elsayed , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 292 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Diabetic cardiomyopathy (DCM) is myocardial dysfunction in absence of significant coronary artery disease, hypertension or valvular disease. There is accumulating evidence to suggest a role of vitamin D in the protection against the development of DCM. Aim of the work: Our study was designed to study and compare the role of vitamin D and metformin supplementation on DCM in type 2 diabetic rat. Results: The present findings revealed development DCM in diabetic rats with hyperglycemia and dyslipidemia with a significant increased insulin levels and HOMA IR in diabetic rats. A significant decrease in VDR, beclin I and SERCAII gene expression in cardiac tissues of diabetic rats was recorded. Treatment of diabetes with metformin, vitamin D or both, improved the cardiac functions and resulted in a significant improvement of glycemic control, lipid metabolism and a significant increase in the expression of SERCA2, Beclin 1 and VDR. Histopathological examination showed collagen fibers deposition. in hearts of diabetic rats, that was decreased by treatment with metformin, vitamin D or both. Conclusion: Our results showed that vitamin D or metformin administration to the diabetic rats improved the functional performance of the hearts, through its effects on lipid profile and glycemic control. Vitamin D acts as antifibrotic agent and also through increases autophagy, Ca2+ homeostasis was improved and increases the expression of SERCAII in cardiac tissue and cause upregulation of vitamin D receptor in the heart. These results were confirmed by the reduction of biomarkers of DCM and histopathological examination. Both drugs in combination resulted in synergistic action as regard most of measured parameters. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cardiomyopathy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Echocardiography |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Type II diabetes |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nashwa Eltablawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samah Elattar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shaimaa Nasr Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.M.Sc.2016.Do.E | 01010110069691000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.M.Sc.2016.Do.E | 01020110069691000 | 22.09.2023 | CD - Rom | 69691.CD |