Circulating hematopoietic derived fibrocytes in chronic hepatitis C patients with liver fibrosis / (Record no. 57930)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03550cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031552.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 161004s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.Ph.D.2015.Ol.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ola Badr Metwally |
| 245 10 - TITLE STATEMENT | |
| Title | Circulating hematopoietic derived fibrocytes in chronic hepatitis C patients with liver fibrosis / |
| Statement of responsibility, etc. | Ola Badr Metwally ; Supervised Samia. H. Rizk , Nora E. I. Elbassiouni , Hassan A. A. Elgarim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة مساهمة الخلايا الليفية المستمدة من الخلايا المكونة للدم في التليف الكبدي للمرضي المصابين بالتهاب الكبدي الفيروسي سي المزمن |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ola Badr Metwally , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Chronic liver disease is a world wide common pathology characterized by an inflammatory and fibrotic process that may lead to progressive evolution from chronic hepatitis to cirrhosis. Bone marrow derived fibrocytes may play an important role in pathogenesis and resolution of liver fibrosis. These cells may offer new approaches for better understanding the pathogenesis of liver fibrosis. Aim of the work: We aim to define the proportion of circulating fibrocytes with hematopoietic progenitor origin as defined by CD45 and CD34 positivity and to assess whether they are increased in patients with chronic C hepatitis in correlation to the degree of liver fibrosis. Results: Data demonstrated a significant increase in the circulating levels of GM-CSF, TGF- Ý and Ü-SMA, along with a significant increased expression of CXCR4 in conjunction with a significant increase in the co expression of CD34, CD45 and collagen type I positive cells in different groups of patients compared to control group, denoting the presence of an increased proportion of circulating fibrocytes in peripheral blood of these patients. Data also revealed that the expression of CD34, CD45, collagen type I and CXCR4 positive fibrocytes, in peripheral blood, increased in step wise fashion in conjunction with worsening severity of liver disease. Conclusion: Our data showed a progressive increase of circulating fibrocytes in peripheral blood in patients with chronic liver disease which matched the advancement of the disease and the intensification of liver fibrosis. Liver fibrosis is associated with increased levels of circulating TGF-Ý1 and lipopolysaccharide, activation of myofibroblasts, and extensive deposition of extracellular matrix, mostly collagen Type I. TGF-Ý and LPS play a critical role in fibrogenesis and trigger fibrocyte recruitment to the injured liver promoting their differentiation into collagen type I producing myofibroblast, supporting that fibrocytes may become a novel target for anti fibrotic therapy |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chronic liver diseases |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fibrocytes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatitis C virus |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hassan Ahmed A. Elgarim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nora E. I. Elbassiouni Ibrahim, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia. Hassan Rizk , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.Ph.D.2015.Ol.C | 01010110069733000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.Ph.D.2015.Ol.C | 01020110069733000 | 22.09.2023 | CD - Rom | 69733.CD |