Biomarkers assessment for detection of hepatocellular carcinoma / (Record no. 58005)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03221cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031554.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 161010s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.Ph.D.2016.Ma.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mohammed Abdelgwad |
| 245 10 - TITLE STATEMENT | |
| Title | Biomarkers assessment for detection of hepatocellular carcinoma / |
| Statement of responsibility, etc. | Marwa Mohammed Abdelgwad ; Supervised Samar Ali Marzouk , Dina Sabry Abdelfattah , Tamer Mahmoud Elbaz |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم الدلالات الحيوية فى الكشف عن سرطان الخلايا الكبدية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Mohammed Abdelgwad , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 137 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | We prospectively collected 50 control subjects (group I), 70 HCV patients (group II) and 100 HCC patients (group III) from HCC multidisciplinary clinic (Kasr El- Eini Hospital, Cairo University, Egypt). AFP was measures as proteinby ELISA. AFP and GP73 gene expression were assessed by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR).Also, AFP- L3 and GP73 serum levels were measured by Western blot technique. Patients' life survivals were calculated. Results: mRNA expression of AFPand GP73 genes in HCC patients [(2.01+0.87) and (4.32+1.56)] were significantly higher than control group [(0.15+0.02) and (0.25+0.03)]& HCV group [(0.86+0.47) and (1.50+0.73)].Protein levels of AFP-L3 and GP73in HCC patients[(11.56+3.85) and (21.75+7.12)], were significantly higher than control group [(0.80+0.36) and (1.40+0.59)] and HCV group [(2.62+1.33) and (7.60+2.90)]. Univariate analysis revealed that up- regulated AFP and GP73 gene expression and AFP-L3 and GP73 protein levels were significant prognostic factors for HCC (p < 0.001). Besides, number of focal lesion and focal lesion size were significant prognostic factors for HCC. Concerning multivariate analysis, up-regulated AFP gene expression and AFP-L3 and GP73 protein levels were significant prognostic factors for HCC (p=0.039,p<0.001, and p=0.039 XI respectively).In addition, focal lesion size (p<0.001) was significantly prognostic factor for HCC. ROC curve comparing AFP, AFP-L3 andGP73 protein levels, showed that GP73 had the highest sensitivity (100%),and followed by AFP-L3 (94.7) and finally AFP with the lowest sensitivity (71.1%). Conclusions: GP73 and AFP-L3 are more sensitive markers than AFP for early detection of HCC patients. Also, both proved to be essential prognostic factors in univariate and multivariate analyses. Key words: Alpha fetoprotein -L3, Golgi protein 73, HCC, HCV |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alpha fetoprotein -L3 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Golgi protein 73 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HCC |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry Abdelfattah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samar Ali Marzouk , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tamer Mahmoud Elbaz , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Enas |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.Ph.D.2016.Ma.B | 01010110069782000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.Ph.D.2016.Ma.B | 01020110069782000 | 22.09.2023 | CD - Rom | 69782.CD |