MARC details
| 000 -LEADER |
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| fixed length control field |
03406cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
161024s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.11.16.M.Sc.2016.No.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Noha Mohamed Hisham Sayed |
| 245 12 - TITLE STATEMENT |
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| Title |
A comparative histological study on the possible effect of ginger and alpha lipoic acid on cerebellum of rat model of streptozotocin-induced diabetes mellitus / |
| Statement of responsibility, etc. |
Noha Mohamed Hisham Sayed ; Supervised Hend Shafik Bassiouny , Nagwa Abdel Wahab Ahmed , Marwa Mohamed Yousry Abdelkader |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة هستولوجية مقارنة على التأثير المحتمل للزنجبيل وحمض ألفا لايبويك على مخيخ الجرذ المصاب بمرض السكرى المحدث بالستربتوزوتوسين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Noha Mohamed Hisham Sayed , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
127 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background and objectives: Diabetes mellitus is a multifactorial disorder, associated with increased morbidity and mortality. Oxidative stress is one of the most important mechanisms of diabetic complications. This work was planned to evaluate and compare the possible effects of ginger and alpha lipoic acid on cerebellum of streptozotocin (STZ) -induced diabetic rats.Materials and Methods: Thirty adult male albino rats were divided into: control and experimental groups. After diabetic induction by STZ, experimental group were further subdivided into untreated diabetic group, ginger-treated group that received 500 mg of ginger /kg/day for 6 weeks, and alpha lipoic acid (ALA)-treated group that received 100 mg of ALA /kg/day for 6 weeks. Sections from left lobe of cerebellum were processed for histological (H&E), immunohistochemical staining for glial fibrillary acidic protein (GFAP), morphometric and statistical studies.Results: Degeneration (pyknosis, karyorrhexis, chromatolysis, swelling), loss, disorganization and migration of Purkinje cells to the granular layer; decreased granular layer thickness, vacuolations around Purkinje cells and in the molecular layer were observed in untreated group. Also, vacuolations with vascular congestion and extravasation were detected in the white matter. GFAP immunoreactive astrocytes were increased 2reactive gliosis3 in untreated group. Both treated groups recorded morphological improvement, with increased number of Purkinje cells (PCs) and thickness of granular layer. GFAP positive astrocytes decreased in both treated groups. These findings were confirmed by morphometric and statistical analysis.Conclusion: This work points to the antioxidant protective effect of ginger and alpha lipoic acid against the oxidative damage of diabetes on cerebellum. ALA has superior role when compared to ginger in protecting PCs and ameliorating reactive gliosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Alpha lipoic acid |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Diabetes mellitus |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Ginger |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hend Shafik Bassiouny , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Marwa Mohamed Yousry Abdelkader , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nagwa Abdelwahab Ahmed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Enas |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
