MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03127cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
161026s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.M.Sc.2016.Na.U |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Naira Mohamed Mustafa Abdelhamid |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Urinary and plasma cell-free DNA integrity as biomarkers for prostate cancer urinary and plasma cell-free DNA Integrity as biomarkers for prostate cancer / |
| Statement of responsibility, etc. |
Naira Mohamed Mustafa Abdelhamid ; Supervised Dina Farouk Elgayar , Walaa Ahmed Rabie , Mahmoud Abdelhamid |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
قياس درجه تماسك االاحماض النوويه الحره في البول والبلازما كمؤشر حيوى للكشف عن سرطان البروستاتا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Naira Mohamed Mustafa Abdelhamid , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
130 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Cell free DNA (cfDNA) is DNA circulating freely in blood stream. It originates from different sources including apoptotic cells which generate small fragments of cfDNA and necrotic cells which generate large fragments of cfDNA. cfDNA integrity is the ratio of longer DNA fragments to shorter ones. The purpose of the present study was to assess the utility of plasma and urine cfDNA integrity as non-invasive screening and diagnostic biomarkers for prostate cancer (PCa) in comparison to the well established tPSA. The current study also aimed at detection of superiority of plasma and urine cfDNA integrity regarding their diagnostic efficacy in PCa. Subjects and methods: This study was conducted on (110) subjects divided into three groups; group (I) compromises (46) PCa patients, group (II) compromises (44) patients with benign prostate hyperplasia (BPH) and group (III) compromises (20) apparently healthy individuals as a control group. Plasma and urine cfDNA integrity were measured using SYBR green based quantitative Polymerase chain reaction (qPCR) for ALU repeats by measuring the ratio of longer fragments ALU 247 bp to shorter fragments ALU 115 bp. Results: The results of this study revealed that plasma and urine cfDNA integrity were statistically significantly higher in PCa group compared to BPH group and control group (p<0.001). However, plasma cfDNA integrity was superior to urine cfDNA integrity in discriminating PCa patients from BPH patients and healthy controls. Conclusion: From these results, it could be concluded that plasma and urine cfDNA integrity might be used as both screening and diagnostic tests for prostate cancer. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Benign prostatic hyperplasia |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Cell free DNA integrity |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Prostate cancer |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dina Farouk Elgayar , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mahmoud Abdelhamid , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walaa Ahmed Rabie , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samah |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
