Stem cell evaluation by ALDH1A1 expression in ovarian epithelial tumors / (Record no. 58328)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03135cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 161026s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.27.M.Sc.2016.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Maha Emad Eldein Muhammad Hussein |
| 245 10 - TITLE STATEMENT | |
| Title | Stem cell evaluation by ALDH1A1 expression in ovarian epithelial tumors / |
| Statement of responsibility, etc. | Maha Emad Eldein Muhammad Hussein ; Supervised Ahmed Mahmoud Abdelaziz , Hala Naguib Hosni , Rasha Ahmed Khairy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم الخلايا الجذعية بواسطة تعبير ايه ال دى اتش١ أ١ فى أورام المبيض الطلائية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Maha Emad Eldein Muhammad Hussein , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Increasing evidence has proposed that tumors contain tumors initiating cells or cancer stem cells (CSCs) that are responsible for its progression and relapse. Aldehyde dehydrogenase 1A1 (ALDH1A1) has recently been identified as a marker for cancer stem cells in some human malignancies including ovarian epithelial cancer. Aim of Work: The assessment of immunohistochemical expression of ALDH1A1 in epithelial ovarian tumors, tracking stem cells during ovarian cancer development and its correlation with the clinicopathological features of such tumors. Methods: This study consisted of 42 cases of ovarian epithelial tumors, classified as 14 cases of benign cystadenomas, 14 cases of borderline tumors and 14 cases of carcinomas. Immunohistochemical reactions were carried out by using ALDH1A1 monoclonal antibody. Cases were classified into two groups, low ALDH1 expression and high ALDH1 expression. Results: Immunohistochemical staining of ALDH1A1 displayed a heterogeneous expression pattern, with differences in the distribution and intensity of positivity. High ALDH1 expression was detected in 26 cases (62%) out of the forty-two studied cases of ovarian tumors. The positivity of ALDH1 was significantly higher in the malignant tumors (86%) than in benign and borderline tumors (50%) (p value = 0.025). There was a significant correlation between ALDH1expression score and the tumor grade (p value = 0.05) where the highest expression of ALDH1 was detected among high grade tumors; grades II & III (100%). More expression of ALDH1A1 was noticed in cases with advanced stage but without statistically significant relation (P = 0.42). Highest ALDH1A1 expression was noticed in cases of serous type tumors (71%) and endometrioid type tumors (100%), although it doesn't reach statistical significance |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ALDH1A1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer stem cells |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ovarian epithelial tumors |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mahmoud Abdelaziz, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Naguib Hosni, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rasha Ahmed Khairy , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shaima |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.27.M.Sc.2016.Ma.S | 01010110069977000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.27.M.Sc.2016.Ma.S | 01020110069977000 | 22.09.2023 | CD - Rom | 69977.CD |