MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02729cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
161115s2016 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.M.Sc.2016.Hu.V |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Huda Ali Moustafa Karmani |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Value of circulating GPC3 m RNA in detecting patient with hepatocellular carcinoma / |
| Statement of responsibility, etc. |
Huda Ali Moustafa Karmani ; Supervised Nehad Ahmad Mosaad , Ashraf Omar Abdelaziz , Yassmin Taha Elshewey |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دور الحامض الريبوزومى الرسولى للجليبكان 3 فى الكشف عن المرضى المصابين بسرطان الكب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Huda Ali Moustafa Karmani , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
133 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Aim: Is to test the clinical performance of GLYPICAN 3 gene expression as a new and specific diagnostic molecular marker in hepatocellular carcinoma by real time PCR and its protein level in serum by ELISA. The serum GPC3 protein and GPC 3 m-RNA level were measured in 30 patients with HCC and 25 patients with cirrhotic liver disease (CLD) and 25 normal healthy control by RT-PCR and by ELISA. The median values of GPC3 m-RNA by RT-PCR in patients with HCC and with CLD and in control group were 2.68ng/mL, 0.843ng/mL and 0.2ng/ml respectively. We found There was no statistically significant elevation between the HCC group as compared to the CLD groups with (p = 0.407), while both groups were significantly higher than control group (p = 0.001). The median values of serum GPC3 protein by ELISA in patients with HCC and with CLD and in control group were 2.9ng/mL, 2.4ng/ml and 2.1ng/mL, respectively. We found that there was no statistically significant difference between the HCC and the CLD groups with (p = 0.488), while both groups were significantly higher than control group (p = 0.004). The median values of serum AFP by ELISA in patients with HCC and with CLD and in control groups were 171.0 ng/mL,13ng/ml and 2.3ng/mL, respectively. We found that. There was statistically significant difference between the HCC and the CLD groups with (p=0.000). And both of them were statistcally higher than the control group p = 0.000 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
ELISA |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Glypican-3 |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hepatocellular carcinoma |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ashraf Omar Abdelaziz , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nehad Ahmad Mosaad , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yassmin Taha Elshewey , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
