Assessment of lusitropic effect of phosphodiesterase -5 inhibitors and erythropoietin as new threaputic modality in treatment of diastolic heart failure in rats / (Record no. 58635)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03281cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031614.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 161115s2016 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2016.In.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Inas Anas Abdelmonem Harb |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of lusitropic effect of phosphodiesterase -5 inhibitors and erythropoietin as new threaputic modality in treatment of diastolic heart failure in rats / |
| Statement of responsibility, etc. | Inas Anas Abdelmonem Harb ; Supervised Soheir Ali Abdelwahed , Hisham Attia Awad , Essam Fouad Alalkamy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التأثير محفز الإنبساط لمجموعة مثبطات إنزيم فسفودايستيراذ 5والإيرثروبيوتين كبديل علاجي جديد لقصور القلب الإنبساطي في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Inas Anas Abdelmonem Harb , |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 151 , 11 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Despite advances in the management of heart failure, the prognosis of these patients remains poor. The results of the randomized clinical trials in patients with DHF (or HFPEF) have demonstrated that while neurohumoral antagonists such as beta blockers, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers are effective in treatment of systolic heart failure (SHF), they do not decrease morbidity and mortality in DHF (Redfield et al., 2003). Development of new forms of interventions remains a challenging task (Lloyd-Jones et al., 2010). Aim: The aim of this work is assessment of lusitropic effect of phosphodiesterase -5 inhibitors (sildenafil) and EPO in a model of diastolic heart failure in female albino rats induced by NG-nitro-L-arginine methyl ester (L-NAME). In addition, to assess the effect of the aforementioned drugs on left ventricle haemodynamic parameters and left ventricular remodeling. Results: In the present study treatment with L-NAME revealed, significant reduction in the mean LVEF and LVFS compared to that recorded in normal group . While milrinone, sildenafil, erythropoietin and combination treatment treated groups showed significant increase in the mean LVEF and LVFS compared to that recorded in L-NAME treated group. Regards ECG records, QT interval prolonged with L-NAME administration compared to that recorded in normal group. While treatment with milrinone , sildenafil and combination treatment showed significant shortening of QT interval compare to that recorded in L-NAME treated group. On the other hand , erythropoietin reduction of QT interval was non-significant compare to that recorded in L-NAME treatment |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ECHO cardiography |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diastolic heart failure |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sildenafil |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Essam Fouad Alalkamy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hisham Attia Awad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Ali Abdelwahed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2016.In.A | 01010110070153000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2016.In.A | 01020110070153000 | 22.09.2023 | CD - Rom | 70153.CD |