MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02533cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
161128s2016 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.05.M.Sc.2016.Ah.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ahmed Ali Mohammed Ibrahim Elbatrawy |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Design, synthesis and antitumor activity of novel pyrazolopyrimidine derivatives / |
| Statement of responsibility, etc. |
Ahmed Ali Mohammed Ibrahim Elbatrawy ; Supervised Samir M. Elmoghazy , Riham F. George |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تصميم وتشييد مشتقات جديدة من البيرازولوبيريميدين كمضادات للأورام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ahmed Ali Mohammed Ibrahim Elbatrawy , |
| Date of publication, distribution, etc. |
2016 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
144 P. : |
| Other physical details |
facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
In this thesis, novel series of pyrazolopyrimidines and pyrazolotriazolopyrimidine were designed. Molecular modelling techniques were used to support the design. 6-Substituted pyrazolo]3,4-d[pyrimidine derivatives IV, V, un/substituted benzylidene hydrazinyl derivatives VIa-c, benzohydrazide derivatives VIIa-c, pyrazolo[4,3-e][1,2,4]triazolo[4,3- a]pyrimidine derivatives IXa-c, Xa-c, XI, XIIa-c, XIII and XIVa,b were synthesized. Enzyme binding assay to Abelson tyrosine kinase (Abl) was carried out on most of the synthesized compounds. The most active derivatives as Abl inhibitors were further screened for their cytotoxic acitivity against leukemia K-562 cell line. The p-methoxy benzohydrazide VIIb and its unsubstituted derivative VIIa were the most active agents toward K-562 cytotoxicity assay with IC50 values of 0.05 and 0.07 æM, respectively. Moreover, all compounds were evaluated for their antitumor activity against colon HCT116 and vulvar epidermoid A431 cancer cell lines. Aim of the work The objective of this work was to design and synthesize new compounds as Abl inhibitors. The design of these compounds was based on the previous SAR studies of this class and supported by the molecular modelling technique. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Antitumor activity of novel |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Novel series of pyrazolopyrimidines |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyrazolopyrimidine derivatives |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Riham Francois George , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Samir Mohamed Elmoghazy , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Soheir |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
